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API Process Intermediates & Related Compounds

2-Chloro-2′,5′-difluoroacetophenone

Available on request

Buy 2-Chloro-2′,5′-difluoroacetophenone (CAS 60468-36-2) from Zemixal: C8H5ClF2O, COA and SDS with every lot, worldwide shipping.

Pack sizes
2-Chloro-2′,5′-difluoroacetophenone chemical structure
CAS number60468-36-2
FormulaC8H5ClF2O
Molar mass190.57 g/mol
Physical formSolid
InChIKeyHJWDDTDVBUFTCP-UHFFFAOYSA-N
IUPAC name2-chloro-1-(2,5-difluorophenyl)ethanone

About 2-Chloro-2′,5′-difluoroacetophenone

Researchers and plant chemists source 2-Chloro-2′,5′-difluoroacetophenone from Zemixal for routine and specialised work. Key data: CAS 60468-36-2, formula C8H5ClF2O and molar mass 190.57 g/mol. It is handled as a solid.

Use cases we see most often

  • API route development
  • Impurity fate & purge studies
  • Analytical method development
  • Fine chemical synthesis

Handling and storage

It carries the GHS signal word Danger (H302, H314 and H335), so wear gloves and eye protection and work with good ventilation.

Order it in 10 mg, 25 mg, 50 mg and 100 mg packs or ask for a bulk quotation. Each lot travels with a batch certificate of analysis and a 16-section SDS. Add it to your quote list and our team replies with price, lead time and shipping options within one business day.

Reference standards for Acetophenone

See every impurity, metabolite and related compound we list for this API.

Acetophenone standards

Typical uses

  • API route development
  • Impurity fate & purge studies
  • Analytical method development
  • Fine chemical synthesis

Applications

Specifications and identifiers

Specifications of 2-Chloro-2′,5′-difluoroacetophenone
Product name2-Chloro-2′,5′-difluoroacetophenone
Catalogue numberZX-044764
CAS number60468-36-2
IUPAC name2-chloro-1-(2,5-difluorophenyl)ethanone
Molecular formulaC8H5ClF2O
Molar mass190.57 g/mol
Exact mass189.9997
Physical formSolid
XLogP32.4
H-bond donors / acceptors0 / 3
Topological polar surface area17.1 Ų
InChIKeyHJWDDTDVBUFTCP-UHFFFAOYSA-N
SMILESC1=CC(=C(C=C1F)C(=O)CCl)F
PubChem CID4989978
Synonyms2-chloro-1-(2,5-difluorophenyl)ethan-1-one, a-Chloro-2',5'-difluoroacetophenone, 2,5-difluorophenacyl chloride, Ethanone, 2-chloro-1-(2,5-difluorophenyl)-, Ethanone,2-chloro-1-(2,5-difluorophenyl)-, 1-(2,5-difluorophenyl)-2-chloroethan-1-one, 2-chloro-1-(2,5-difluoro-phenyl)-ethanone, 2-Chloro-2 inverted exclamation mark ,5 inverted exclamation mark -difluoroacetophenone

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

GHS05 Corrosive
Corrosive
GHS07 Irritant or harmful
Irritant or harmful

Signal word Danger

  • H302Harmful if swallowed
  • H314Causes severe skin burns and eye damage
  • H335May cause respiratory irritation

Precautionary statements P260, P261, P264, P270, P271, P280, P301 + P317, P301 + P330 + P331, P302 + P361 + P354, P304 + P340, P305 + P354 + P338, P316, P319, P321, P330, P363, P403 + P233, P405, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of 2-Chloro-2′,5′-difluoroacetophenone
10 mgQuoted on request
25 mgQuoted on request
50 mgQuoted on request
100 mgQuoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about 2-Chloro-2′,5′-difluoroacetophenone

Which CAS number identifies 2-Chloro-2′,5′-difluoroacetophenone?
2-Chloro-2′,5′-difluoroacetophenone is registered under CAS 60468-36-2. You may also see it listed as 2-chloro-1-(2,5-difluorophenyl)ethan-1-one, a-Chloro-2',5'-difluoroacetophenone, 2,5-difluorophenacyl chloride. Our catalogue number for this item is ZX-044764.
What are the formula and molar mass of 2-Chloro-2′,5′-difluoroacetophenone?
For 2-Chloro-2′,5′-difluoroacetophenone, its formula is C8H5ClF2O and its molar mass is 190.57 g/mol. The systematic (IUPAC) name is 2-chloro-1-(2,5-difluorophenyl)ethanone. InChIKey HJWDDTDVBUFTCP-UHFFFAOYSA-N lets you match it in any structure database.
How is 2-Chloro-2′,5′-difluoroacetophenone used in pharmaceutical QC?
2-Chloro-2′,5′-difluoroacetophenone is a characterised reference material linked to Acetophenone. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.
What grade and pack sizes are available for 2-Chloro-2′,5′-difluoroacetophenone?
The grade and assay are confirmed on the quotation and the batch COA. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.
Which documents come with 2-Chloro-2′,5′-difluoroacetophenone?
Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.
Can Zemixal ship 2-Chloro-2′,5′-difluoroacetophenone to my country?
Yes. Because 2-Chloro-2′,5′-difluoroacetophenone is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

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