(4S)-4-Amino-5-(dimethylamino)-5-oxopentanoic acid
- CAS
- 87733-70-8
- Formula
- C7H14N2O3
- MW
- 174.21 g/mol
ZX-039424
API Impurities
(+/-)Amethopterin
Reference StandardAvailable on request
Buy (+/-)Amethopterin (CAS 60388-53-6) from Zemixal: C20H22N8O5, COA and SDS with every lot, worldwide shipping. Packs from 10 mg.
CAS number60388-53-6
FormulaC20H22N8O5
Molar mass454.4 g/mol
Physical formSolid
HS code38229090
InChIKeyFBOZXECLQNJBKD-UHFFFAOYSA-N
IUPAC name2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
About (+/-)Amethopterin
(+/-)Amethopterin is supplied by Zemixal as a characterised reference material for Methotrexate analysis. Key data (Reference Standard): CAS 60388-53-6, formula C20H22N8O5 and molar mass 454.4 g/mol. It is handled as a solid.
Where it is used
- Analytical method development
- Method validation (AMV)
- QC release testing
- ANDA / DMF filings
Storage and safety notes
Hazard communication follows GHS (Danger: H301, H315, H319 and H360). Our SDS lists exposure controls and first-aid measures.
Order it in 10 mg, 25 mg, 50 mg and 100 mg packs or ask for a bulk quotation. Every shipment includes a certificate of analysis with characterisation data. Request pricing online and we confirm availability, documentation and freight to your country.
Reference standards for Methotrexate
See every impurity, metabolite and related compound we list for this API.
Methotrexate standardsTypical uses
- Analytical method development
- Method validation (AMV)
- QC release testing
- ANDA / DMF filings
Applications
Specifications and identifiers
| Product name | (+/-)Amethopterin |
|---|---|
| Catalogue number | ZX-043581 |
| CAS number | 60388-53-6 |
| IUPAC name | 2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid |
| Molecular formula | C20H22N8O5 |
| Molar mass | 454.4 g/mol |
| Exact mass | 454.1713 |
| Grade | Reference Standard |
| Physical form | Solid |
| XLogP3 | -1.8 |
| H-bond donors / acceptors | 5 / 12 |
| Topological polar surface area | 211 Ų |
| HS code | 38229090 |
| InChIKey | FBOZXECLQNJBKD-UHFFFAOYSA-N |
| SMILES | CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O |
| PubChem CID | 4112 |
| Synonyms | DL-Methotrexate, DL-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, Methotrexate, (A+-)-, DL-Amethopterin, Amethopterin (R,S), 2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid, Methotrexate, (+/-)-, ( inverted exclamation markA)-Methotrexate, 6-Mtx (DL), 2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid |
Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.
Safety and GHS hazards
Signal word Danger
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H360May damage fertility or the unborn child
Precautionary statements P203, P264, P264 + P265, P270, P280, P301 + P316, P302 + P352, P305 + P351 + P338, P318, P321, P330, P332 + P317, P337 + P317, P362 + P364, P405, P501
Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.
Pack sizes
| 10 mg | Quoted on request | |
| 25 mg | Quoted on request | |
| 50 mg | Quoted on request | |
| 100 mg | Quoted on request |
Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.
Questions about (+/-)Amethopterin
Which CAS number identifies (+/-)Amethopterin?
(+/-)Amethopterin is registered under CAS 60388-53-6. You may also see it listed as DL-Methotrexate, DL-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, Methotrexate, (A+-)-. Our catalogue number for this item is ZX-043581.
What are the formula and molar mass of (+/-)Amethopterin?
For (+/-)Amethopterin, its formula is C20H22N8O5 and its molar mass is 454.4 g/mol. The systematic (IUPAC) name is 2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid. InChIKey FBOZXECLQNJBKD-UHFFFAOYSA-N lets you match it in any structure database.
How is (+/-)Amethopterin used in pharmaceutical QC?
(+/-)Amethopterin is a characterised reference material linked to Methotrexate. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.
What grade and pack sizes are available for (+/-)Amethopterin?
This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.
Which documents come with (+/-)Amethopterin?
Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.
Can Zemixal ship (+/-)Amethopterin to my country?
Yes. Because (+/-)Amethopterin is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.
More Methotrexate standards
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