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API Impurities

5-Methyltetrahydrofolic Acid

Reference StandardAvailable on request

Buy 5-Methyltetrahydrofolic Acid (CAS 134-35-0) from Zemixal: C20H25N7O6, COA and SDS with every lot, worldwide shipping.

Pack sizes
5-Methyltetrahydrofolic Acid chemical structure
CAS number134-35-0
FormulaC20H25N7O6
Molar mass459.5 g/mol
Physical formSolid
HS code38229090
InChIKeyZNOVTXRBGFNYRX-ABLWVSNPSA-N
IUPAC name(2S)-2-[[4-[(2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

About 5-Methyltetrahydrofolic Acid

5-Methyltetrahydrofolic Acid is supplied by Zemixal as a characterised reference material for Folic Acid analysis. Identity at a glance (Reference Standard): CAS 134-35-0, formula C20H25N7O6 and molar mass 459.5 g/mol. It is handled as a solid.

Use cases we see most often

  • Analytical method development
  • Method validation (AMV)
  • QC release testing
  • ANDA / DMF filings

Handling and storage

Hazard communication follows GHS (Warning: H317). Our SDS lists exposure controls and first-aid measures.

Available as 10 mg, 25 mg, 50 mg and 100 mg. Larger or split packs can be arranged. Each lot travels with a certificate of analysis with characterisation data. Add it to your quote list and our team replies with price, lead time and shipping options within one business day.

Reference standards for Folic Acid

See every impurity, metabolite and related compound we list for this API.

Folic Acid standards

Typical uses

  • Analytical method development
  • Method validation (AMV)
  • QC release testing
  • ANDA / DMF filings

Applications

Specifications and identifiers

Specifications of 5-Methyltetrahydrofolic Acid
Product name5-Methyltetrahydrofolic Acid
Catalogue numberZX-029621
CAS number134-35-0
IUPAC name(2S)-2-[[4-[(2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
Molecular formulaC20H25N7O6
Molar mass459.5 g/mol
Exact mass459.1866
GradeReference Standard
Physical formSolid
XLogP3-0.5
H-bond donors / acceptors7 / 10
Topological polar surface area198 Ų
HS code38229090
InChIKeyZNOVTXRBGFNYRX-ABLWVSNPSA-N
SMILESCN1C(CNC2=C1C(=O)NC(=N2)N)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
PubChem CID135415868
SynonymsN-Methyltetrahydrofolic Acid, Prefolic A, n5-methyltetrahydrofolate, n5-methyltetrahydrofolic acid, n-methyltetrahydrofolate, N5-Methyltetrahydropteroylglutamate, 5-methyltetrahydropteroylglutamic acid, 5-methyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid, 5-methyl-THF, Methyl folate, 5-Methyltetrahydrofolate, 5-Methyl THF

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

GHS07 Irritant or harmful
Irritant or harmful

Signal word Warning

  • H317May cause an allergic skin reaction

Precautionary statements P261, P272, P280, P302 + P352, P321, P333 + P317, P362 + P364, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of 5-Methyltetrahydrofolic Acid
10 mgQuoted on request
25 mgQuoted on request
50 mgQuoted on request
100 mgQuoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about 5-Methyltetrahydrofolic Acid

Which CAS number identifies 5-Methyltetrahydrofolic Acid?
5-Methyltetrahydrofolic Acid is registered under CAS 134-35-0. You may also see it listed as N-Methyltetrahydrofolic Acid, Prefolic A, n5-methyltetrahydrofolate. Our catalogue number for this item is ZX-029621.
What are the formula and molar mass of 5-Methyltetrahydrofolic Acid?
For 5-Methyltetrahydrofolic Acid, its formula is C20H25N7O6 and its molar mass is 459.5 g/mol. The systematic (IUPAC) name is (2S)-2-[[4-[(2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid. InChIKey ZNOVTXRBGFNYRX-ABLWVSNPSA-N lets you match it in any structure database.
How is 5-Methyltetrahydrofolic Acid used in pharmaceutical QC?
5-Methyltetrahydrofolic Acid is a characterised reference material linked to Folic Acid. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.
What grade and pack sizes are available for 5-Methyltetrahydrofolic Acid?
This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.
Which documents come with 5-Methyltetrahydrofolic Acid?
Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.
Can Zemixal ship 5-Methyltetrahydrofolic Acid to my country?
Yes. Because 5-Methyltetrahydrofolic Acid is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

More Folic Acid standards

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