Crizotinib

Name: Crizotinib
Brand: Zemixal
SKU: ZX-006473

Reference StandardIn stock

Crizotinib (CAS 877399-52-5) supplier Zemixal: C21H22Cl2FN5O, COA and SDS with every lot, worldwide shipping. Part of our API Reference Standards range.

Pack sizes

CAS number877399-52-5

FormulaC₂₁H₂₂Cl₂FN₅O

Molar mass450.3 g/mol

Physical formSolid

HS code38229090

InChIKeyKTEIFNKAUNYNJU-GFCCVEGCSA-N

IUPAC name3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

About Crizotinib

Analytical teams working on Crizotinib use Crizotinib as a qualified comparison standard. For your records (Reference Standard), the material is defined by CAS 877399-52-5, formula C21H22Cl2FN5O and molar mass 450.3 g/mol. It is handled as a solid.

Where it is used

Identification & assay
Method development & validation
QC reference material

Safe handling

It carries the GHS signal word Danger (H317, H318, H319 and H341), so wear gloves and eye protection and work with good ventilation.

Available as 10 mg, 25 mg, 50 mg, 100 mg and 250 mg. Larger or split packs can be arranged. You receive a certificate of analysis with characterisation data with each order. Send an enquiry through the quote panel and you get a formal offer with Incoterms and delivery time.

Reference standards for Crizotinib

See every impurity, metabolite and related compound we list for this API.

Crizotinib standards

Typical uses

Identification & assay
Method development & validation
QC reference material

Applications

Pharmaceutical Manufacturing and QC Research Labs and Universities

Specifications and identifiers

Specifications of Crizotinib
Product name	Crizotinib
Catalogue number	ZX-006473
CAS number	877399-52-5
IUPAC name	3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
Molecular formula	C₂₁H₂₂Cl₂FN₅O
Molar mass	450.3 g/mol
Exact mass	449.1185
Grade	Reference Standard
Physical form	Solid
XLogP3	3.7
H-bond donors / acceptors	2 / 6
Topological polar surface area	78 Å²
HS code	38229090
InChIKey	KTEIFNKAUNYNJU-GFCCVEGCSA-N
SMILES	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
PubChem CID	11626560
Synonyms	Xalkori, (R)-crizotinib, MET Tyrosine Kinase Inhibitor PF-02341066, Crizotinib (PF-02341066), Crizotinib (PF-2341066), C21H22Cl2FN5O, Xalkori (TN), 877399-52-5 (free base), Crizotinib (Standard), PF-2341066,Crizotinib, Crizotinib (JAN/USAN/INN), Crizotinib - Bio-X trade mark

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

Corrosive

Irritant or harmful

Health hazard

Hazardous to the environment

Signal word Danger

H317May cause an allergic skin reaction
H318Causes serious eye damage
H319Causes serious eye irritation
H341Suspected of causing genetic defects
H400Very toxic to aquatic life

Precautionary statements P203, P261, P264 + P265, P272, P273, P280, P302 + P352, P305 + P351 + P338, P305 + P354 + P338, P317, P318, P321, P333 + P317, P337 + P317, P362 + P364, P391, P405, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of Crizotinib
10 mg	Quoted on request
25 mg	Quoted on request
50 mg	Quoted on request
100 mg	Quoted on request
250 mg	Quoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about Crizotinib

Which CAS number identifies Crizotinib?

Crizotinib is registered under CAS 877399-52-5. You may also see it listed as Xalkori, (R)-crizotinib, MET Tyrosine Kinase Inhibitor PF-02341066. Our catalogue number for this item is ZX-006473.

What are the formula and molar mass of Crizotinib?

For Crizotinib, its formula is C21H22Cl2FN5O and its molar mass is 450.3 g/mol. The systematic (IUPAC) name is 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine. InChIKey KTEIFNKAUNYNJU-GFCCVEGCSA-N lets you match it in any structure database.

How is Crizotinib used in pharmaceutical QC?

Crizotinib is a characterised reference material linked to Crizotinib. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.

What grade and pack sizes are available for Crizotinib?

This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg, 250 mg. Larger quantities and custom packing can be quoted on request.

Which documents come with Crizotinib?

Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.

Can Zemixal ship Crizotinib to my country?

Yes. Because Crizotinib is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

More Crizotinib standards

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