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API Reference Standards

Afatinib

Reference StandardAvailable on request

Afatinib (CAS 850140-72-6) supplier Zemixal: C24H25ClFN5O3, COA and SDS with every lot, worldwide shipping. Packs from 10 mg.

Pack sizes
Afatinib chemical structure
CAS number850140-72-6
FormulaC24H25ClFN5O3
Molar mass485.9 g/mol
Physical formSolid
HS code38229090
InChIKeyULXXDDBFHOBEHA-CWDCEQMOSA-N
IUPAC name(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide

About Afatinib

Zemixal lists Afatinib for laboratories that identify, quantify or control Afatinib and its related substances. Identity at a glance (Reference Standard): CAS 850140-72-6, formula C24H25ClFN5O3 and molar mass 485.9 g/mol. It is handled as a solid.

Where it is used

  • Identification & assay
  • Method development & validation
  • QC reference material

Safe handling

Classified under GHS with signal word Warning and hazard statements H302, H315, H319 and H335. Read the SDS before first use.

Available as 10 mg, 25 mg, 50 mg and 100 mg. Larger or split packs can be arranged. You receive a certificate of analysis with characterisation data with each order. Request pricing online and we confirm availability, documentation and freight to your country.

Reference standards for Afatinib

See every impurity, metabolite and related compound we list for this API.

Afatinib standards

Typical uses

  • Identification & assay
  • Method development & validation
  • QC reference material

Applications

Pharmaceutical Manufacturing and QCResearch Labs and Universities

Specifications and identifiers

Specifications of Afatinib
Product nameAfatinib
Catalogue numberZX-023162
CAS number850140-72-6
IUPAC name(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
Molecular formulaC24H25ClFN5O3
Molar mass485.9 g/mol
Exact mass485.163
GradeReference Standard
Physical formSolid
XLogP33.6
H-bond donors / acceptors2 / 8
Topological polar surface area88.6 Ų
HS code38229090
InChIKeyULXXDDBFHOBEHA-CWDCEQMOSA-N
SMILESCN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
PubChem CID10184653
SynonymsBIBW 2992, BIBW-2992, (E/Z)-Afatinib, Afatinib (BIBW2992), Afatinib free base, Afatinib, Free Base, BIBW2992 (Tovok), Afatinib E-Isomer, (S)-Afatinib, BIBW2992,Afatinib, Afatinib - Bio-X trade mark

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

GHS07 Irritant or harmful
Irritant or harmful
GHS08 Health hazard
Health hazard

Signal word Warning

  • H302Harmful if swallowed
  • H315Causes skin irritation
  • H319Causes serious eye irritation
  • H335May cause respiratory irritation
  • H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements P260, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of Afatinib
10 mgQuoted on request
25 mgQuoted on request
50 mgQuoted on request
100 mgQuoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about Afatinib

Which CAS number identifies Afatinib?
Afatinib is registered under CAS 850140-72-6. You may also see it listed as BIBW 2992, BIBW-2992, (E/Z)-Afatinib. Our catalogue number for this item is ZX-023162.
What are the formula and molar mass of Afatinib?
For Afatinib, its formula is C24H25ClFN5O3 and its molar mass is 485.9 g/mol. The systematic (IUPAC) name is (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide. InChIKey ULXXDDBFHOBEHA-CWDCEQMOSA-N lets you match it in any structure database.
How is Afatinib used in pharmaceutical QC?
Afatinib is a characterised reference material linked to Afatinib. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.
What grade and pack sizes are available for Afatinib?
This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.
Which documents come with Afatinib?
Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.
Can Zemixal ship Afatinib to my country?
Yes. Because Afatinib is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

More Afatinib standards

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