Impurity reference standards
Afatinib impurity standards
Zemixal lists 32 reference materials related to Afatinib, covering the drug substance itself, its process impurities and the products it forms on storage. Among them are 1 isotope-labelled standard, 4 metabolites or hydroxylated analogues and 1 degradation product.
32reference materials
1isotope labelled
4metabolites
1degradants
Batches are supplied with a certificate of analysis, and the supporting spectra can be sent ahead of a purchase order so your QA team can review them. They are bought for system suitability, peak identification, quantitation against limits and the impurity justification sections of regulatory submissions.
By impurity type
Isotope labelled1Deuterated, 13C or 15N internal standards
Metabolites4Hydroxy, desmethyl and conjugated forms
Degradants1N-oxides, dimers, lactones and breakdown products
Counts are based on product names. One compound can fall into more than one type.
All Afatinib reference materials
1–32 of 32 standards
(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
- CAS
- 2085843-51-0
- Formula
- C22H23ClFN5O2
- MW
- 443.9 g/mol
ZX-023164
(R)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
- CAS
- 402855-07-6
- Formula
- C18H14ClFN4O4
- MW
- 404.8 g/mol
ZX-027781
(S,E)-4-(Dimethylamino)-N-(4-((4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
- CAS
- 2413212-25-4
- Formula
- C24H26FN5O3
- MW
- 451.5 g/mol
ZX-027677
(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-2-enamide
- CAS
- 2121530-37-6
- Formula
- C22H20ClFN4O4
- MW
- 458.9 g/mol
ZX-020500
(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
- CAS
- 2223677-64-1
- Formula
- C22H20ClFN4O3
- MW
- 442.9 g/mol
ZX-020501
(S,E)-N-(4-((3,4-Dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
- CAS
- 2223677-63-0
- Formula
- C24H25Cl2N5O3
- MW
- 502.4 g/mol
ZX-020506
(S,E)-N-(4-((3,4-Difluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
- CAS
- 2223677-62-9
- Formula
- C24H25F2N5O3
- MW
- 469.5 g/mol
ZX-020507
(S,Z)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
- CAS
- 1680184-59-1
- Formula
- C24H25ClFN5O3
- MW
- 485.9 g/mol
ZX-020497
(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
- CAS
- 314771-88-5
- Formula
- C18H14ClFN4O4
- MW
- 404.8 g/mol
ZX-019808
(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide
- CAS
- 2223677-60-7
- Formula
- C19H16ClFN4O3
- MW
- 402.8 g/mol
ZX-019809
(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy) quinazoline-4,6-diamine
- CAS
- 314771-76-1
- Formula
- C18H16ClFN4O2
- MW
- 374.8 g/mol
ZX-019805
(S)-N4-(3-chlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
- CAS
- 2413212-09-4
- Formula
- C18H17ClN4O2
- MW
- 356.8 g/mol
ZX-020499
(S)-N4-(3,4-Difluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
- CAS
- 2044709-72-8
- Formula
- C18H16F2N4O2
- MW
- 358.3 g/mol
ZX-027782
(S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
- CAS
- 2413212-07-2
- Formula
- C18H17FN4O2
- MW
- 340.4 g/mol
ZX-027676
1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
- CAS
- 2223677-58-3
- Formula
- C22H20ClFN4O4
- MW
- 458.9 g/mol
ZX-019804
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
- CAS
- 179552-74-0
- Formula
- C15H10ClFN4O3
- MW
- 348.71 g/mol
ZX-027678
N-(4-Chloro-3-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
- CAS
- 2475095-50-0
- Formula
- C14H7ClF2N4O2
- MW
- 336.68 g/mol
ZX-023165
trans-4-Dimethylaminocrotonic acid hydrochloride
- CAS
- 848133-35-7
- Formula
- C6H12ClNO2
- MW
- 165.62 g/mol
ZX-034462
Questions
Afatinib impurities, answered
How many Afatinib impurity standards does Zemixal list?
The catalogue currently lists 32 compounds for Afatinib, including 1 isotope-labelled standard, 4 metabolites or hydroxylated analogues and 1 degradation product. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.
What documents come with a Afatinib impurity standard?
A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.
Can Zemixal make a Afatinib impurity that is not listed?
Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.
Are isotope-labelled Afatinib standards available?
Yes. 1 stable-isotope labelled compound is listed, suitable as internal standards for LC-MS bioanalysis and trace impurity quantitation.