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Pharmacopeial Impurities (EP / USP / BP)

Naloxone EP Impurity D

Reference StandardAvailable on request

Naloxone EP Impurity D (CAS 26451-92-3) supplier Zemixal: C19H19NO4, COA and SDS with every lot, worldwide shipping. Quotes within one business day.

Pack sizes
Naloxone EP Impurity D chemical structure
CAS number26451-92-3
FormulaC19H19NO4
Molar mass325.4 g/mol
Physical formSolid
HS code38229090
InChIKeyVHFYKBURRFNDQL-GRGSLBFTSA-N
IUPAC name(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

About Naloxone EP Impurity D

Naloxone EP Impurity D belongs to the Naloxone reference-standard family in the Zemixal catalogue. Identity at a glance (Reference Standard): CAS 26451-92-3, formula C19H19NO4 and molar mass 325.4 g/mol. It is handled as a solid.

Where it is used

  • Pharmacopeial method verification
  • Impurity profiling
  • QC release testing
  • ANDA / DMF filings

Safe handling

Classified under GHS with signal word Warning and hazard statements H302, H315, H319 and H332. Read the SDS before first use.

Available as 10 mg, 25 mg, 50 mg and 100 mg. Larger or split packs can be arranged. You receive a certificate of analysis with characterisation data with each order. Request pricing online and we confirm availability, documentation and freight to your country.

Reference standards for Naloxone

See every impurity, metabolite and related compound we list for this API.

Naloxone standards

Typical uses

  • Pharmacopeial method verification
  • Impurity profiling
  • QC release testing
  • ANDA / DMF filings

Applications

Pharmaceutical Manufacturing and QCResearch Labs and Universities

Grade guides

Ph. Eur. Grade (European Pharmacopoeia)

Specifications and identifiers

Specifications of Naloxone EP Impurity D
Product nameNaloxone EP Impurity D
Catalogue numberZX-032831
CAS number26451-92-3
IUPAC name(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Molecular formulaC19H19NO4
Molar mass325.4 g/mol
Exact mass325.1314
GradeReference Standard
Physical formSolid
XLogP31.4
H-bond donors / acceptors2 / 5
Topological polar surface area70 Ų
HS code38229090
InChIKeyVHFYKBURRFNDQL-GRGSLBFTSA-N
SMILESC=CCN1CC[C@]23[C@@H]4C(=O)C=C[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O
PubChem CID9897757
SynonymsNaloxone Hydrochloride EP Impurity D, Naloxone Hydrochloride - Impurity D, 7,8-Didehydronaloxone, (5alpha)-7,8-Didehydro-4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)morphinan-6-one, Morphinan-6-one, 7,8-didehydro-4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, (5alpha)-, Naloxone hydrochloride dihydrate impurity D, 7,8-Didehydro Naloxone

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

GHS07 Irritant or harmful
Irritant or harmful

Signal word Warning

  • H302Harmful if swallowed
  • H315Causes skin irritation
  • H319Causes serious eye irritation
  • H332Harmful if inhaled
  • H335May cause respiratory irritation
  • H336May cause drowsiness or dizziness

Precautionary statements P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of Naloxone EP Impurity D
10 mgQuoted on request
25 mgQuoted on request
50 mgQuoted on request
100 mgQuoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about Naloxone EP Impurity D

Which CAS number identifies Naloxone EP Impurity D?
Naloxone EP Impurity D is registered under CAS 26451-92-3. You may also see it listed as Naloxone Hydrochloride EP Impurity D, Naloxone Hydrochloride - Impurity D, 7,8-Didehydronaloxone. Our catalogue number for this item is ZX-032831.
What are the formula and molar mass of Naloxone EP Impurity D?
For Naloxone EP Impurity D, its formula is C19H19NO4 and its molar mass is 325.4 g/mol. The systematic (IUPAC) name is (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one. InChIKey VHFYKBURRFNDQL-GRGSLBFTSA-N lets you match it in any structure database.
How is Naloxone EP Impurity D used in pharmaceutical QC?
Naloxone EP Impurity D is a characterised reference material linked to Naloxone. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.
What grade and pack sizes are available for Naloxone EP Impurity D?
This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.
Which documents come with Naloxone EP Impurity D?
Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.
Can Zemixal ship Naloxone EP Impurity D to my country?
Yes. Because Naloxone EP Impurity D is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

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