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API Impurities

Sacubitril Impurity 22

Reference StandardIn stock

Order Sacubitril Impurity 22 (CAS 1012341-48-8) online at Zemixal. Request a quote with price, lead time and documents. Quotes within one business day.

Pack sizes
Sacubitril Impurity 22 chemical structure
CAS number1012341-48-8
FormulaC23H27NO4
Molar mass381.5 g/mol
Physical formSolid
HS code38229090
InChIKeyJXTNUXJSXXIIFE-VISDOYDDSA-N
IUPAC name(E,4R)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pent-2-enoic acid

About Sacubitril Impurity 22

Analytical teams working on Sacubitril use Sacubitril Impurity 22 as a qualified comparison standard. Key data (Reference Standard): CAS 1012341-48-8, formula C23H27NO4 and molar mass 381.5 g/mol. It is handled as a solid.

Common uses in the lab and plant

  • Analytical method development
  • Method validation (AMV)
  • QC release testing
  • ANDA / DMF filings

Available as 10 mg, 25 mg, 50 mg, 100 mg and 250 mg. Larger or split packs can be arranged. Every shipment includes a certificate of analysis with characterisation data. Request pricing online and we confirm availability, documentation and freight to your country.

Reference standards for Sacubitril

See every impurity, metabolite and related compound we list for this API.

Sacubitril standards

Typical uses

  • Analytical method development
  • Method validation (AMV)
  • QC release testing
  • ANDA / DMF filings

Applications

Pharmaceutical Manufacturing and QCResearch Labs and Universities

Specifications and identifiers

Specifications of Sacubitril Impurity 22
Product nameSacubitril Impurity 22
Catalogue numberZX-005323
CAS number1012341-48-8
IUPAC name(E,4R)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pent-2-enoic acid
Molecular formulaC23H27NO4
Molar mass381.5 g/mol
Exact mass381.194
GradeReference Standard
Physical formSolid
XLogP34.7
H-bond donors / acceptors2 / 4
Topological polar surface area75.6 Ų
HS code38229090
InChIKeyJXTNUXJSXXIIFE-VISDOYDDSA-N
SMILESC/C(=C\[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)OC(C)(C)C)/C(=O)O
PubChem CID56846981
Synonyms(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic Acid, (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid, LCZ-696 Impurity 58, (E,4R)-4-(tert-butoxycarbonylamino)-2-methyl-5-(4-phenylphenyl)pent-2-enoic acid, Sacubitril Impurity I, Valsartan Impurity 28, (R,E)-5-(4-Biphenylyl)-4-(Boc-amino)-2-methyl-2-pentenoic Acid, (2E,4R)-4-{[(tert-butoxy)carbonyl]amino}-2-methyl-5-(4-phenylphenyl)pent-2-enoic acid, (E)-(R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpent-2-enoic acid, (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoicacid, (2E,4R)-5-([1,1'-Biphenyl]-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpent-2-enoic acid, (2E,4R)-5-{[1,1-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

GHS09 Hazardous to the environment
Hazardous to the environment
  • H411Toxic to aquatic life with long lasting effects
  • H412Harmful to aquatic life with long lasting effects

Precautionary statements P273, P391, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of Sacubitril Impurity 22
10 mgQuoted on request
25 mgQuoted on request
50 mgQuoted on request
100 mgQuoted on request
250 mgQuoted on request
500 mgQuoted on request
1 gQuoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about Sacubitril Impurity 22

Which CAS number identifies Sacubitril Impurity 22?
Sacubitril Impurity 22 is registered under CAS 1012341-48-8. You may also see it listed as (R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic Acid, (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid, LCZ-696 Impurity 58. Our catalogue number for this item is ZX-005323.
What are the formula and molar mass of Sacubitril Impurity 22?
For Sacubitril Impurity 22, its formula is C23H27NO4 and its molar mass is 381.5 g/mol. The systematic (IUPAC) name is (E,4R)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pent-2-enoic acid. InChIKey JXTNUXJSXXIIFE-VISDOYDDSA-N lets you match it in any structure database.
How is Sacubitril Impurity 22 used in pharmaceutical QC?
Sacubitril Impurity 22 is a characterised reference material linked to Sacubitril. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.
What grade and pack sizes are available for Sacubitril Impurity 22?
This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg. Larger quantities and custom packing can be quoted on request.
Which documents come with Sacubitril Impurity 22?
Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.
Can Zemixal ship Sacubitril Impurity 22 to my country?
Yes. Because Sacubitril Impurity 22 is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

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