Impurity reference standards
Sacubitril impurity standards
Zemixal lists 67 reference materials related to Sacubitril, covering the drug substance itself, its process impurities and the products it forms on storage. Among them are 1 isotope-labelled standard and 2 metabolites or hydroxylated analogues.
67reference materials
1isotope labelled
2metabolites
Each lot ships with a certificate of analysis, and characterisation data such as 1H-NMR, mass spectrum and HPLC purity can be shared before you order. They are bought for system suitability, peak identification, quantitation against limits and the impurity justification sections of regulatory submissions.
By impurity type
Isotope labelled1Deuterated, 13C or 15N internal standards
Metabolites2Hydroxy, desmethyl and conjugated forms
Counts are based on product names. One compound can fall into more than one type.
All Sacubitril reference materials
1–60 of 67 standards
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester
- CAS
- 752174-62-2
- Formula
- C20H25NO2
- MW
- 311.4 g/mol
ZX-011801
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
- CAS
- 149690-12-0
- Formula
- C20H26ClNO2
- MW
- 347.9 g/mol
ZX-011802
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(4-ethoxy-4-oxobutanamido)-2-methylpentanoic acid
- CAS
- 149709-49-9
- Formula
- C24H29NO5
- MW
- 411.5 g/mol
ZX-032364
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(4-isopropoxy-4-oxobutanamido)-2-methylpentanoic acid
- CAS
- 2459446-51-4
- Formula
- C25H31NO5
- MW
- 425.5 g/mol
ZX-026871
(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid
- CAS
- 1012341-50-2
- Formula
- C23H29NO4
- MW
- 383.5 g/mol
ZX-011803
(2R,4S)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-(4-ethoxy-4-oxobutanamido)-2-methylpentanoate
- CAS
- 2216747-18-9
- Formula
- C26H33NO5
- MW
- 439.5 g/mol
ZX-032362
(2R,4S)-Isopropyl 5-([1,1'-biphenyl]-4-yl)-4-(4-isopropoxy-4-oxobutanamido)-2-methylpentanoate
- CAS
- 2216755-67-6
- Formula
- C28H37NO5
- MW
- 467.6 g/mol
ZX-026872
(2S,4R)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic Acid
- CAS
- 1012341-54-6
- Formula
- C23H29NO4
- MW
- 383.5 g/mol
ZX-026863
(2S,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid
- CAS
- 1012341-52-4
- Formula
- C23H29NO4
- MW
- 383.5 g/mol
ZX-032355
(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpent-2-enoic acid
- CAS
- 2459446-56-9
- Formula
- C18H19NO2
- MW
- 281.3 g/mol
ZX-032360
(R,E)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate
- CAS
- 1817838-91-7
- Formula
- C25H31NO4
- MW
- 409.5 g/mol
ZX-026869
(R)-1-(1-([1,1'-Biphenyl]-4-yl)-3-chloropropan-2-yl)pyrrolidine-2,5-dione
- CAS
- 1573000-36-8
- Formula
- C19H18ClNO2
- MW
- 327.8 g/mol
ZX-032357
(R)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate
- CAS
- 149818-98-4
- Formula
- C21H25NO4
- MW
- 355.4 g/mol
ZX-032359
(R)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-acetamidopropanoate
- CAS
- 164460-67-7
- Formula
- C18H19NO3
- MW
- 297.3 g/mol
ZX-032367
(R)-N-(1-([1,1'-Biphenyl]-4-yl)-3-hydroxypropan-2-yl)acetamide
- CAS
- 1660147-07-8
- Formula
- C17H19NO2
- MW
- 269.34 g/mol
ZX-032369
(S)-1-([1,1′-Biphenyl]-4-yl)-3-chloropropan-2-ol
- CAS
- 1573000-28-8
- Formula
- C15H15ClO
- MW
- 246.73 g/mol
ZX-022725
(αR,γR)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid
- CAS
- 1012341-56-8
- Formula
- C23H29NO4
- MW
- 383.5 g/mol
ZX-026864
[(1R)-2-(Biphenyl-4-yl)-1-formylethyl]carbamic acid tert-butyl ester
- CAS
- 149709-58-0
- Formula
- C20H23NO3
- MW
- 325.4 g/mol
ZX-026865
1-Ethoxy-1-oxopropan-2-yl)triphenylphosphonium bromide
- CAS
- 30018-16-7
- Formula
- C23H24BrO2P
- MW
- 443.3 g/mol
ZX-034470
1,1-Dimethylethyl N-[(1S)-2-[1,1′-biphenyl]-4-yl-1-formylethyl]carbamate
- CAS
- 182192-86-5
- Formula
- C20H23NO3
- MW
- 325.4 g/mol
ZX-032365
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-isopropoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid
- CAS
- 2514965-95-6
- Formula
- C25H31NO5
- MW
- 425.5 g/mol
ZX-026867
4-((3R,5S)-5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoic Acid
- CAS
- 2459446-54-7
- Formula
- C22H23NO4
- MW
- 365.4 g/mol
ZX-032354
Ethyl (2S,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride
- CAS
- 149690-13-1
- Formula
- C20H26ClNO2
- MW
- 347.9 g/mol
ZX-032358
Ethyl (S,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate
- CAS
- 2131788-25-3
- Formula
- C25H31NO4
- MW
- 409.5 g/mol
ZX-032366
Isopropyl 4-((3R,5S)-5-([1,1'-biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoate
- CAS
- 2149600-13-3
- Formula
- C25H29NO4
- MW
- 407.5 g/mol
ZX-032363
N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester
- CAS
- 1426129-50-1
- Formula
- C20H25NO3
- MW
- 327.4 g/mol
ZX-022724
Questions
Sacubitril impurities, answered
How many Sacubitril impurity standards does Zemixal list?
The catalogue currently lists 67 compounds for Sacubitril, including 1 isotope-labelled standard and 2 metabolites or hydroxylated analogues. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.
What documents come with a Sacubitril impurity standard?
A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.
Can Zemixal make a Sacubitril impurity that is not listed?
Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.
Are isotope-labelled Sacubitril standards available?
Yes. 1 stable-isotope labelled compound is listed, suitable as internal standards for LC-MS bioanalysis and trace impurity quantitation.