(E)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine
- CAS
- 1715011-38-3
- Formula
- C12H17NO4S
- MW
- 271.33 g/mol
ZX-023339
Impurity reference standards
Apremilast impurity standards
Zemixal lists 45 reference materials related to Apremilast, covering the drug substance itself, its process impurities and the products it forms on storage. Among them are 3 pharmacopoeial impurities, 1 isotope-labelled standard, 8 metabolites or hydroxylated analogues and 1 degradation product.
45reference materials
3pharmacopoeial
1isotope labelled
8metabolites
Each lot ships with a certificate of analysis, and characterisation data such as 1H-NMR, mass spectrum and HPLC purity can be shared before you order. Typical uses are method development and validation, relative response factor work, forced degradation studies and the impurity sections of ANDA, DMF or CEP filings.
By impurity type
Pharmacopoeial3EP, USP, BP or JP named impurities
Isotope labelled1Deuterated, 13C or 15N internal standards
Metabolites8Hydroxy, desmethyl and conjugated forms
Degradants1N-oxides, dimers, lactones and breakdown products
Counts are based on product names. One compound can fall into more than one type.
All Apremilast reference materials
1–45 of 45 standards
(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-l- leucine salt
- CAS
- 608141-43-1
- Formula
- C20H34N2O7S
- MW
- 446.6 g/mol
ZX-023333
(S)-2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
- CAS
- 2077897-93-7
- Formula
- C20H21NO6S
- MW
- 403.5 g/mol
ZX-028051
(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-5-yl)acetamide
- CAS
- 2201974-01-6
- Formula
- C22H24N2O7S
- MW
- 460.5 g/mol
ZX-028052
(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5-hydroxy-1,3-dioxoisoindolin-4-yl)acetamide
- CAS
- 2096492-43-0
- Formula
- C22H24N2O8S
- MW
- 476.5 g/mol
ZX-028054
1-(3-ethoxy-4-methoxyphenyl)-2-((2-hydroxyethyl)sulfonyl)ethanone
- Formula
- C13H18O6S
- MW
- 302.35 g/mol
ZX-011892
1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone
- CAS
- 1450657-28-9
- Formula
- C12H16O5S
- MW
- 272.32 g/mol
ZX-011893
1-(3,4-Diethoxyphenyl)-2-(methyl sulfonyl)ethanamine
- CAS
- 1284768-38-2
- Formula
- C13H21NO4S
- MW
- 287.38 g/mol
ZX-028053
2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-4-nitroisoindoline-1,3-dione
- CAS
- 253168-82-0
- Formula
- C20H20N2O8S
- MW
- 448.4 g/mol
ZX-028055
2-Ethoxy-1-methoxy-4-(2-(methylsulfonyl)ethyl)benzene
- CAS
- 2489621-73-8
- Formula
- C12H18O4S
- MW
- 258.34 g/mol
ZX-012009
2-Ethoxy-1-methoxy-4-(2-methylsulfonylethenyl)benzene
- CAS
- 1831833-38-5
- Formula
- C12H16O4S
- MW
- 256.32 g/mol
ZX-023335
4-Amino-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
- CAS
- 253168-83-1
- Formula
- C20H22N2O6S
- MW
- 418.5 g/mol
ZX-023337
N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide
- CAS
- 6296-53-3
- Formula
- C10H7NO4
- MW
- 205.17 g/mol
ZX-012640
Questions
Apremilast impurities, answered
How many Apremilast impurity standards does Zemixal list?
The catalogue currently lists 45 compounds for Apremilast, including 3 pharmacopoeial impurities, 1 isotope-labelled standard, 8 metabolites or hydroxylated analogues and 1 degradation product. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.
What documents come with a Apremilast impurity standard?
A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.
Can Zemixal make a Apremilast impurity that is not listed?
Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.
Are isotope-labelled Apremilast standards available?
Yes. 1 stable-isotope labelled compound is listed, suitable as internal standards for LC-MS bioanalysis and trace impurity quantitation.