Impurity reference standards

Bedaquiline impurity standards

For Bedaquiline, the Zemixal catalogue holds 17 impurity and reference standards that support release testing, stability programmes and regulatory dossiers. Counted by type, there are 1 metabolite or hydroxylated analogue and 1 degradation product.

17reference materials

1metabolites

1degradants

Every standard comes with a certificate of analysis. Structure confirmation data, typically NMR, MS and chromatographic purity, is available on request. They are bought for system suitability, peak identification, quantitation against limits and the impurity justification sections of regulatory submissions.

By impurity type

Metabolites1Hydroxy, desmethyl and conjugated forms

Degradants1N-oxides, dimers, lactones and breakdown products

Counts are based on product names. One compound can fall into more than one type.

All Bedaquiline reference materials

1–17 of 17 standards

(1S,2R)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol

CAS: 857086-93-2
Formula: C₃₂H₃₁BrN₂O₂
MW: 555.5 g/mol

ZX-019966

(1S,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-2-yl)-1-phenylbutan-2-ol

CAS: 2924118-18-1
Formula: C₃₂H₃₁BrN₂O₂
MW: 555.5 g/mol

ZX-023505

(R)-(-)-Binaphthyl-2,2'-diyl hydrogen Phosphate

CAS: 39648-67-4
Formula: C₂₀H₁₂O₄P-
MW: 347.3 g/mol

ZX-036806

3-(Dimethylamino)-1-(Naphthalen-1-yl)propan-1-one HCl

CAS: 5409-58-5
Formula: C₁₅H₁₈ClNO
MW: 263.76 g/mol

ZX-019967

3-Benzyl-2-methoxyquinoline

CAS: 1381767-10-7
Formula: C₁₇H₁₅NO
MW: 249.31 g/mol

ZX-028200

3-Benzyl-6-bromo-2-methoxyquinoline

CAS: 654655-69-3
Formula: C₁₇H₁₄BrNO
MW: 328.2 g/mol

ZX-019968

Bedaquiline

CAS: 843663-66-1
Formula: C₃₂H₃₁BrN₂O₂
MW: 555.5 g/mol

ZX-023500

Bedaquiline Des-Bromo Impurity

CAS: 2122862-01-3
Formula: C₃₂H₃₂N₂O₂
MW: 476.6 g/mol

ZX-023504

Bedaquiline Enantiomer Mixture (Fumarate salt)

CAS: 2747938-36-7
Formula: C₃₆H₃₅BrN₂O₆
MW: 671.6 g/mol

ZX-047983

Bedaquiline fumarate

CAS: 845533-86-0
Formula: C₃₆H₃₅BrN₂O₆
MW: 671.6 g/mol

ZX-020788

Bedaquiline N-Oxide Impurity

CAS: 2924118-12-5
Formula: C₃₂H₃₁BrN₂O₃
MW: 571.5 g/mol

ZX-028199

Desmethoxy Bedaquiline

CAS: 2924118-10-3
Formula: C₃₁H₂₉BrN₂O₂
MW: 541.5 g/mol

ZX-023503

N-(4-Bromophenyl)-benzenepropanamide

CAS: 316146-27-7
Formula: C₁₅H₁₄BrNO
MW: 304.18 g/mol

ZX-035211

N-Benzoyl-L-Aspartic acid

CAS: 4631-12-3
Formula: C₁₁H₁₁NO₅
MW: 237.21 g/mol

ZX-042221

N-Desmethyl Bedaquiline

CAS: 861709-47-9
Formula: C₃₁H₂₉BrN₂O₂
MW: 541.5 g/mol

ZX-023501

Rac-Bedaquiline

CAS: 654655-80-8
Formula: C₃₂H₃₁BrN₂O₂
MW: 555.5 g/mol

ZX-023502

Rel-(1R,2R)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol

CAS: 654653-92-6
Formula: C₆₄H₆₂Br₂N₄O₄
MW: 1111 g/mol

ZX-028201

Questions

Bedaquiline impurities, answered

What Bedaquiline reference materials are available?

The catalogue currently lists 17 compounds for Bedaquiline, including 1 metabolite or hydroxylated analogue and 1 degradation product. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.

What documents come with a Bedaquiline impurity standard?

A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.

Can Zemixal make a Bedaquiline impurity that is not listed?

Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.