(3R,5RS,6RS)-6-(3-Chlorophenyl)-6-Hydroxy-5-Methyl-3-Thiomorpholine Carboxylic Acid
- CAS
- 1246812-57-6
- Formula
- C12H14ClNO3S
- MW
- 287.76 g/mol
ZX-028372
Impurity reference standards
Bupropion impurity standards
62 characterised compounds linked to Bupropion are catalogued here, from named pharmacopoeial impurities to synthesis intermediates and breakdown products. Highlights of the range are 6 pharmacopoeial impurities, 1 nitrosamine, 3 isotope-labelled standards and 8 metabolites or hydroxylated analogues.
62reference materials
6pharmacopoeial
1nitrosamines
3isotope labelled
Batches are supplied with a certificate of analysis, and the supporting spectra can be sent ahead of a purchase order so your QA team can review them. Typical uses are method development and validation, relative response factor work, forced degradation studies and the impurity sections of ANDA, DMF or CEP filings. The nitrosamine entries support ICH M7 risk assessments and confirmatory testing at trace levels.
By impurity type
Pharmacopoeial6EP, USP, BP or JP named impurities
Nitrosamines1N-nitroso impurities for ICH M7 work
Isotope labelled3Deuterated, 13C or 15N internal standards
Metabolites8Hydroxy, desmethyl and conjugated forms
Counts are based on product names. One compound can fall into more than one type.
All Bupropion reference materials
1–60 of 62 standards
2-(Butylamino)-1-(3-Chlorophenyl)propan-1-One Hydrochloride
- CAS
- 1049701-04-3
- Formula
- C13H18ClNO.HCl
- MW
- 276.2 g/mol
ZX-038893
2-(tert-Butylamino)-3',5'-dichloropropiophenone Hydrochloride
- CAS
- 1346603-00-6
- Formula
- C13H18Cl3NO
- MW
- 310.6 g/mol
ZX-023675
2-Amino-1-(3-Chlorophenyl)-1-Propanone Hydrochloride
- CAS
- 2227990-16-9
- Formula
- C9H11Cl2NO
- MW
- 220.09 g/mol
ZX-023678
Bupropion USP Related Compound B (Hcl Salt)
- CAS
- 1049718-43-5
- Formula
- C13H19BrClNO
- MW
- 320.65 g/mol
ZX-020079
Questions
Bupropion impurities, answered
How many Bupropion impurity standards does Zemixal list?
The catalogue currently lists 62 compounds for Bupropion, including 6 pharmacopoeial impurities, 1 nitrosamine, 3 isotope-labelled standards and 8 metabolites or hydroxylated analogues. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.
What documents come with a Bupropion impurity standard?
A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.
Can Zemixal make a Bupropion impurity that is not listed?
Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.
Do you supply Bupropion nitrosamine impurities?
Yes. 1 N-nitroso compound is listed for Bupropion. They are used for confirmatory testing and method validation in line with ICH M7 and the nitrosamine guidance from the major regulators.
Are isotope-labelled Bupropion standards available?
Yes. 3 stable-isotope labelled compounds are listed, suitable as internal standards for LC-MS bioanalysis and trace impurity quantitation.