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Impurity reference standards

Cabozantinib impurity standards

31 characterised compounds linked to Cabozantinib are catalogued here, from named pharmacopoeial impurities to synthesis intermediates and breakdown products. Highlights of the range are 1 isotope-labelled standard, 5 metabolites or hydroxylated analogues and 3 degradation products.

31reference materials
1isotope labelled
5metabolites
3degradants
Cabozantinib WS structure
Parent API

Cabozantinib WS

CAS
849217-68-1
Formula
C28H24FN3O5
MW
501.5 g/mol
Code
ZX-006443

Every standard comes with a certificate of analysis. Structure confirmation data, typically NMR, MS and chromatographic purity, is available on request. They are bought for system suitability, peak identification, quantitation against limits and the impurity justification sections of regulatory submissions.

By impurity type

Isotope labelled1Deuterated, 13C or 15N internal standards
Metabolites5Hydroxy, desmethyl and conjugated forms
Degradants3N-oxides, dimers, lactones and breakdown products

Counts are based on product names. One compound can fall into more than one type.

All Cabozantinib reference materials

1–31 of 31 standards
Questions

Cabozantinib impurities, answered

How many Cabozantinib impurity standards does Zemixal list?
The catalogue currently lists 31 compounds for Cabozantinib, including 1 isotope-labelled standard, 5 metabolites or hydroxylated analogues and 3 degradation products. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.
What documents come with a Cabozantinib impurity standard?
A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.
Can Zemixal make a Cabozantinib impurity that is not listed?
Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.
Are isotope-labelled Cabozantinib standards available?
Yes. 1 stable-isotope labelled compound is listed, suitable as internal standards for LC-MS bioanalysis and trace impurity quantitation.
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