Impurity reference standards

Ponatinib impurity standards

Zemixal lists 11 reference materials related to Ponatinib, covering the drug substance itself, its process impurities and the products it forms on storage. Among them are 1 metabolite or hydroxylated analogue and 1 degradation product.

11reference materials

1metabolites

1degradants

Batches are supplied with a certificate of analysis, and the supporting spectra can be sent ahead of a purchase order so your QA team can review them. Laboratories use them to validate related-substance methods, set specification limits under ICH Q3A and Q3B, and identify unknown peaks in stability samples.

By impurity type

Metabolites1Hydroxy, desmethyl and conjugated forms

Degradants1N-oxides, dimers, lactones and breakdown products

Counts are based on product names. One compound can fall into more than one type.

All Ponatinib reference materials

1–11 of 11 standards

3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic Acid

CAS: 1300690-48-5
Formula: C₁₆H₁₁N₃O₂
MW: 277.28 g/mol

ZX-022538

3-Bromoimidazo(1,2-b)pyridazine

CAS: 18087-73-5
Formula: C₆H₄BrN₃
MW: 198.02 g/mol

ZX-042372

3,3-(Buta-1,3-diyne-1,4-diyl)bis(4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide)

CAS: 2097674-16-1
Formula: C₄₆H₄₆F₆N₆O₂
MW: 828.9 g/mol

ZX-022537

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

CAS: 694499-26-8
Formula: C₁₃H₁₈F₃N₃
MW: 273.3 g/mol

ZX-022535

7-((Triisopropylsilyl)ethynyl)-3H-imidazo[4,5-b]pyridine

CAS: 2500888-31-1
Formula: C₁₇H₂₅N₃Si
MW: 299.5 g/mol

ZX-041668

Ponatinib

CAS: 943319-70-8
Formula: C₂₉H₂₇F₃N₆O
MW: 532.6 g/mol

ZX-026466

Ponatinib D8

CAS: 1562993-37-6
Formula: C₂₉H₂₇F₃N₆O
MW: 540.6 g/mol

ZX-031914

Ponatinib Ester Impurity

CAS: 1356385-96-0
Formula: C₁₇H₁₃N₃O₂
MW: 291.3 g/mol

ZX-022536

Ponatinib hydrochloride

CAS: 1114544-31-8
Formula: C₂₉H₂₈ClF₃N₆O
MW: 569 g/mol

ZX-036007

Ponatinib N-Desmethyl Analog

CAS: 943319-87-7
Formula: C₂₈H₂₅F₃N₆O
MW: 518.5 g/mol

ZX-020366

Ponatinib N-Oxide

CAS: 2227480-51-3
Formula: C₂₉H₂₇F₃N₆O₂
MW: 548.6 g/mol

ZX-020367

Questions

Ponatinib impurities, answered

How many Ponatinib impurity standards does Zemixal list?

The catalogue currently lists 11 compounds for Ponatinib, including 1 metabolite or hydroxylated analogue and 1 degradation product. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.

What documents come with a Ponatinib impurity standard?

A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.

Can Zemixal make a Ponatinib impurity that is not listed?

Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.