Impurity reference standards

Relugolix impurity standards

For Relugolix, the Zemixal catalogue holds 28 impurity and reference standards that support release testing, stability programmes and regulatory dossiers. Counted by type, there are 1 metabolite or hydroxylated analogue and 1 degradation product.

28reference materials

1metabolites

1degradants

Parent API

Relugolix

CAS: 737789-87-6
Formula: C₂₉H₂₇F₂N₇O₅S
MW: 623.6 g/mol
Code: ZX-006768

Every standard comes with a certificate of analysis. Structure confirmation data, typically NMR, MS and chromatographic purity, is available on request. They are bought for system suitability, peak identification, quantitation against limits and the impurity justification sections of regulatory submissions.

By impurity type

Metabolites1Hydroxy, desmethyl and conjugated forms

Degradants1N-oxides, dimers, lactones and breakdown products

Counts are based on product names. One compound can fall into more than one type.

All Relugolix reference materials

1–28 of 28 standards

1-(1-(2,6-Difluorobenzyl)-3-(6-methoxypyridazin-3-yl)-6-(4-(3-methoxyureido)phenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-5-yl)-N,N-dimethylmethanamine oxide

CAS: 2814571-34-9
Formula: C₂₉H₂₇F₂N₇O₆S
MW: 639.6 g/mol

ZX-026677

1-(4-(1-(2,6-Difluorobenzyl)-3-(6-methoxypyridazin-3-yl)-5-((methylamino)methyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea

CAS: 737790-54-4
Formula: C₂₈H₂₅F₂N₇O₅S
MW: 609.6 g/mol

ZX-026679

1-(4-(1-(2,6-Difluorobenzyl)-3-(6-methoxypyridazin-3-yl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea

CAS: 2681381-03-1
Formula: C₂₇H₂₂F₂N₆O₅S
MW: 580.6 g/mol

ZX-022640

1-(4-(1-(2,6-Difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)urea

CAS: 2814571-30-5
Formula: C₂₈H₂₅F₂N₇O₄S
MW: 593.6 g/mol

ZX-022639

1-Cbz-4-hydroxypiperidine

CAS: 95798-23-5
Formula: C₁₃H₁₇NO₃
MW: 235.28 g/mol

ZX-047758

1,3-Dimethoxyurea

CAS: 6378-51-4
Formula: C₃H₈N₂O₃
MW: 120.11 g/mol

ZX-011879

2-((2,6-Difluorobenzyl)amino)-4-((dimethylamino)methyl)-N-(6-methoxypyridazin-3-yl)-5-(4-(3-methoxyureido)phenyl)thiophene-3-carboxamide

CAS: 2814571-33-8
Formula: C₂₈H₂₉F₂N₇O₄S
MW: 597.6 g/mol

ZX-026678

2-(Chloromethyl)-1,3-difluoro-4-methoxybenzene

CAS: 1508154-46-8
Formula: C₈H₇ClF₂O
MW: 192.59 g/mol

ZX-042433

2,4-Difluorobenzyl Chloride

CAS: 452-07-3
Formula: C₇H₅ClF₂
MW: 162.56 g/mol

ZX-011944

2,6-Difluoro-3-methoxybenzyl bromide

CAS: 886498-55-1
Formula: C₈H₇BrF₂O
MW: 237.04 g/mol

ZX-042432

Ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-((dimethylamino)methyl)-5-(4-nitrophenyl)thiophene-3-carboxylate

CAS: 1589503-97-8
Formula: C₂₆H₂₇F₂N₃O₆S
MW: 547.6 g/mol

ZX-036103

Ethyl-2-Amino-4-methyl-5-(4-nitro-phenyl)-thiophene-3-carboxylate

CAS: 174072-89-0
Formula: C₁₄H₁₄N₂O₄S
MW: 306.34 g/mol

ZX-032140

Methyl 2,6-difluorobenzoate

CAS: 13671-00-6
Formula: C₈H₆F₂O₂
MW: 172.13 g/mol

ZX-046288

N-Benzyl-N-methyl-1H-imidazole-1-carboxamide

CAS: 548763-27-5
Formula: C₁₂H₁₃N₃O
MW: 215.25 g/mol

ZX-036857

Relugolix

CAS: 737789-87-6
Formula: C₂₉H₂₇F₂N₇O₅S
MW: 623.6 g/mol

ZX-006768

Relugolix Des Methyl Impurity Stage-I

CAS: 308831-94-9
Formula: C₂₄H₂₂F₂N₂O₆S
MW: 504.5 g/mol

ZX-005248

Relugolix Des-Fluoro Nitro Intermediate

Formula: C₂₆H₂₈FN₃O₆S
MW: 529.58 g/mol

ZX-012817

Relugolix Des-Fluoro Nitro Intermediate (Stage-2)

Formula: C₂₄H₂₂BrFN₂O₆S
MW: 565.41 g/mol

ZX-012818

Relugolix Impurity 34

CAS: 1589503-95-6
Formula: C₂₄H₂₃F₂N₃O₆S
MW: 519.5 g/mol

ZX-005249

Relugolix Impurity 5

CAS: 1589504-01-7
Formula: C₃₁H₃₀F₂N₈O₇S
MW: 696.7 g/mol

ZX-032141

Relugolix Impurity 53

CAS: 308831-93-8
Formula: C₁₇H₁₈N₂O₆S
MW: 378.4 g/mol

ZX-047821

Relugolix Impurity 61

CAS: 2814571-32-7
Formula: C₂₆H₂₄F₂N₆O₄S
MW: 554.6 g/mol

ZX-005250

Relugolix Impurity B

CAS: 1589503-93-4
Formula: C₂₇H₂₄F₂N₆O₃S
MW: 550.6 g/mol

ZX-005251

Relugolix Impurity-20 (Stage-V)

CAS: 2767571-66-2
Formula: C₂₆H₂₆F₂N₆O₂S
MW: 524.6 g/mol

ZX-005252

Relugolix KSM 02 Impurity

CAS: 308831-95-0
Formula: C₂₄H₂₁BrF₂N₂O₆S
MW: 583.4 g/mol

ZX-047995

Relugolix NH-OH Impurity (N-1Stage)

CAS: 1589503-96-7
Formula: C₂₇H₂₂F₂N₆O₅S
MW: 580.6 g/mol

ZX-005253

Relugolix NH-OH Impurity (Stage-1)

CAS: 1589503-94-5
Formula: C₆₇H₆₅BrN₇O₁₄PS₄
MW: 1431.4 g/mol

ZX-005254

Relugolix Urea Dimer Impurity

CAS: 2814571-36-1
Formula: C₅₅H₄₆F₄N₁₂O₇S₂
MW: 1127.2 g/mol

ZX-026676

Questions

Relugolix impurities, answered

What Relugolix reference materials are available?

The catalogue currently lists 28 compounds for Relugolix, including 1 metabolite or hydroxylated analogue and 1 degradation product. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.

What documents come with a Relugolix impurity standard?

A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.

Can Zemixal make a Relugolix impurity that is not listed?

Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.