Impurity reference standards
Ruxolitinib impurity standards
For Ruxolitinib, the Zemixal catalogue holds 38 impurity and reference standards that support release testing, stability programmes and regulatory dossiers. Counted by type, there are 3 metabolites or hydroxylated analogues.
38reference materials
3metabolites
Every standard comes with a certificate of analysis. Structure confirmation data, typically NMR, MS and chromatographic purity, is available on request. They are bought for system suitability, peak identification, quantitation against limits and the impurity justification sections of regulatory submissions.
By impurity type
Metabolites3Hydroxy, desmethyl and conjugated forms
Counts are based on product names. One compound can fall into more than one type.
All Ruxolitinib reference materials
1–38 of 38 standards
(R)-(4-(1-(2-Cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate
- CAS
- 1146629-80-2
- Formula
- C23H28N6O2
- MW
- 420.5 g/mol
ZX-032351
(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanamide
- CAS
- 2102675-42-1
- Formula
- C17H20N6O
- MW
- 324.4 g/mol
ZX-026700
(R)-3-(4-Bromo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
- CAS
- 1146629-83-5
- Formula
- C11H14BrN3
- MW
- 268.15 g/mol
ZX-040293
(R)-3-Cyclopentyl-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile
- CAS
- 941685-40-1
- Formula
- C23H32N6OSi
- MW
- 436.6 g/mol
ZX-032348
(R)-3-Cyclopentyl-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile (2S,3S)-2,3-bis(benzoyloxy)succinate
- CAS
- 1236033-04-7
- Formula
- C41H46N6O9Si
- MW
- 794.9 g/mol
ZX-032347
(S)-3-(4-Bromo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
- CAS
- 2183286-19-1
- Formula
- C11H14BrN3
- MW
- 268.15 g/mol
ZX-032350
3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanoic Acid
- CAS
- 3016399-21-3
- Formula
- C17H19N5O2
- MW
- 325.4 g/mol
ZX-026859
Ruxolitinib 7-Hydroxymethyl Impurity (R- Isomer)
- CAS
- 1236033-03-6
- Formula
- C18H20N6O
- MW
- 336.4 g/mol
ZX-005311
Ruxolitinib Impurity 11 (Diastereomeric Mixture)
- CAS
- 1092973-96-0
- Formula
- C17H16N6O
- MW
- 320.3 g/mol
ZX-005313
Ruxolitinib M18 Metabolite (Diastereomeric Mixture)
- CAS
- 1092973-95-9
- Formula
- C17H18N6O
- MW
- 322.4 g/mol
ZX-006343
Ruxolitinib Metabolite 1 (Diastereomeric Mixture)
- CAS
- 1092973-94-8
- Formula
- C17H18N6O
- MW
- 322.4 g/mol
ZX-006344
Ruxolitinib Pyrazole Deazapurine Pyrimidine Impurity
- CAS
- 941685-27-4
- Formula
- C15H21N5OSi
- MW
- 315.45 g/mol
ZX-005318
Questions
Ruxolitinib impurities, answered
What Ruxolitinib reference materials are available?
The catalogue currently lists 38 compounds for Ruxolitinib, including 3 metabolites or hydroxylated analogues. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.
What documents come with a Ruxolitinib impurity standard?
A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.
Can Zemixal make a Ruxolitinib impurity that is not listed?
Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.