Impurity reference standards

Sertraline impurity standards

This page brings together 39 Sertraline related compounds that analytical teams use to identify, quantify and control impurities in the active ingredient and the finished dosage form. The range includes 9 pharmacopoeial impurities, 1 nitrosamine, 3 metabolites or hydroxylated analogues and 1 degradation product.

39reference materials

9pharmacopoeial

1nitrosamines

3metabolites

Parent API

Sertraline

CAS: 79559-97-0
Formula: C₁₇H₁₈Cl₃N
MW: 342.7 g/mol
Code: ZX-004060

Every standard comes with a certificate of analysis. Structure confirmation data, typically NMR, MS and chromatographic purity, is available on request. They are bought for system suitability, peak identification, quantitation against limits and the impurity justification sections of regulatory submissions. For nitrosamine risk evaluation, the N-nitroso standards allow confirmatory LC-MS testing against the acceptable intake limits.

By impurity type

Pharmacopoeial9EP, USP, BP or JP named impurities

Nitrosamines1N-nitroso impurities for ICH M7 work

Metabolites3Hydroxy, desmethyl and conjugated forms

Degradants1N-oxides, dimers, lactones and breakdown products

Counts are based on product names. One compound can fall into more than one type.

All Sertraline reference materials

1–39 of 39 standards

(1R,4S)-Sertraline

CAS: 79951-46-5
Formula: C₁₇H₁₈Cl₃N
MW: 342.7 g/mol

ZX-004262

(1R,4S)-Sertraline Hydrochloride

CAS: 79896-32-5
Formula: C₁₇H₁₈Cl₃N
MW: 342.7 g/mol

ZX-004263

(1RS,4SR)-4-(4-Chlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine

CAS: 107538-97-6
Formula: C₁₇H₁₈ClN
MW: 271.8 g/mol

ZX-032462

(1S,4R) Sertraline Hydrochloride

CAS: 79896-31-4
Formula: C₁₇H₁₈Cl₃N
MW: 342.7 g/mol

ZX-032456

1-(3,4-Dichlorophenyl)-1,2-dihydronaphthalene

CAS: 439134-46-0
Formula: C₁₆H₁₂Cl₂
MW: 275.2 g/mol

ZX-032461

2,3-Isosertraline (Mixture)

CAS: 2124277-87-6
Formula: C₃₄H₃₄Cl₄N₂
MW: 612.5 g/mol

ZX-042495

2,3-Isosertraline Hydrochloride

CAS: 2124277-88-7
Formula: C₁₇H₁₈Cl₃N
MW: 342.7 g/mol

ZX-026916

3,4-Deschlorosertraline

CAS: 55056-87-6
Formula: C₁₇H₂₀ClN
MW: 273.8 g/mol

ZX-046073

4-(3-Chlorophenyl)-3,4-dihydro-1(2H)-naphthalenone

CAS: 82101-37-9
Formula: C₁₆H₁₃ClO
MW: 256.73 g/mol

ZX-042493

Methylamine

CAS: 74-89-5
Formula: CH₅N
MW: 31.06 g/mol

ZX-012623

Methylamine Hydrochloride

CAS: 593-51-1
Formula: CH₆ClN
MW: 67.52 g/mol

ZX-012624

N-[4-(2,3-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine

CAS: 340830-05-9
Formula: C₁₇H₁₅Cl₂N
MW: 304.2 g/mol

ZX-032458

N-[4-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine N-Oxide

CAS: 209473-00-7
Formula: C₁₇H₁₅Cl₂NO
MW: 320.2 g/mol

ZX-026915

N-Desmethyl sertraline

CAS: 87857-41-8
Formula: C₁₆H₁₅Cl₂N
MW: 292.2 g/mol

ZX-032454

N-Hydroxy Sertraline

CAS: 124345-07-9
Formula: C₁₇H₁₇Cl₂NO
MW: 322.2 g/mol

ZX-032459

rac 4-(2,3-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone

CAS: 152448-80-1
Formula: C₁₆H₁₂Cl₂O
MW: 291.2 g/mol

ZX-032455

rac-cis-3-Dechloro Sertraline Hydrochloride

CAS: 79646-00-7
Formula: C₁₇H₁₉Cl₂N
MW: 308.2 g/mol

ZX-026914

rac-cis-Sertraline Mandelate

CAS: 79617-95-1
Formula: C₁₇H₁₇Cl₂N
MW: 306.2 g/mol

ZX-042494

Racemic-Sertraline Hydrochloride

CAS: 79617-89-3
Formula: C₁₇H₁₈Cl₃N
MW: 342.7 g/mol

ZX-032451

Sertraline

CAS: 79559-97-0
Formula: C₁₇H₁₈Cl₃N
MW: 342.7 g/mol

ZX-004060

Sertraline

CAS: 79617-96-2
Formula: C₁₇H₁₇Cl₂N
MW: 306.2 g/mol

ZX-006816

Sertraline 2,3-Dichloro Hydrochloride Isomer

CAS: 1198084-29-5
Formula: C₁₇H₁₈Cl₃N
MW: 342.7 g/mol

ZX-005337

Sertraline Carbamoyl Glucuronide

CAS: 119733-44-7
Formula: C₂₄H₂₅Cl₂NO₈
MW: 526.4 g/mol

ZX-032463

Sertraline Dimethylamino Analog

CAS: 79836-76-3
Formula: C₁₈H₂₀Cl₃N
MW: 356.7 g/mol

ZX-032453

Sertraline EP Impurity A

CAS: 79836-45-6
Formula: C₁₇H₁₇Cl₂N
MW: 306.2 g/mol

ZX-032450

Sertraline EP Impurity A Hydrochloride

CAS: 79617-99-5
Formula: C₁₇H₁₈Cl₃N
MW: 342.7 g/mol

ZX-026910

Sertraline EP Impurity B (Freebase)

CAS: 52758-03-9
Formula: C₁₇H₁₉N
MW: 237.34 g/mol

ZX-005986

Sertraline EP Impurity B (Hydrochloride)

CAS: 52758-05-1
Formula: C₁₇H₂₀ClN
MW: 273.8 g/mol

ZX-005987

Sertraline EP Impurity C

CAS: 107538-91-0
Formula: C₁₇H₁₈ClN
MW: 271.8 g/mol

ZX-005988

Sertraline EP Impurity C (Hydrochloride)

CAS: 79559-98-1
Formula: C₁₇H₁₉Cl₂N
MW: 308.2 g/mol

ZX-005989

Sertraline EP Impurity F

CAS: 155748-61-1
Formula: C₁₆H₁₂Cl₂O
MW: 291.2 g/mol

ZX-026911

Sertraline EP Impurity G (Freebase)

CAS: 79617-98-4
Formula: C₁₇H₁₇Cl₂N
MW: 306.2 g/mol

ZX-005990

Sertraline EP Impurity G (Hydrochloride)

CAS: 79645-15-1
Formula: C₁₇H₁₈Cl₃N
MW: 342.7 g/mol

ZX-005991

Sertraline Nitroso Impurity (Mixture of isomers)

CAS: 3006789-98-3
Formula: C₁₇H₁₆Cl₂N₂O
MW: 335.2 g/mol

ZX-032460

Sertraline Oxime Impurity

CAS: 152642-35-8
Formula: C₁₆H₁₃Cl₂NO
MW: 306.2 g/mol

ZX-032452

Sertraline Phenyl Keto Intermediate

CAS: 14578-68-8
Formula: C₁₆H₁₄O
MW: 222.28 g/mol

ZX-036173

Sertraline Tetralone

CAS: 79560-19-3
Formula: C₁₆H₁₂Cl₂O
MW: 291.2 g/mol

ZX-026913

Sertraline Tetralone Methanamine

CAS: 79560-20-6
Formula: C₁₇H₁₅Cl₂N
MW: 304.2 g/mol

ZX-026912

Sertraline Tetralone S-Isomer

CAS: 124379-29-9
Formula: C₁₆H₁₂Cl₂O
MW: 291.2 g/mol

ZX-032457

Questions

Sertraline impurities, answered

What Sertraline reference materials are available?

The catalogue currently lists 39 compounds for Sertraline, including 9 pharmacopoeial impurities, 1 nitrosamine, 3 metabolites or hydroxylated analogues and 1 degradation product. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.

What documents come with a Sertraline impurity standard?

A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.

Can Zemixal make a Sertraline impurity that is not listed?

Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.

Do you supply Sertraline nitrosamine impurities?

Yes. 1 N-nitroso compound is listed for Sertraline. They are used for confirmatory testing and method validation in line with ICH M7 and the nitrosamine guidance from the major regulators.

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