Impurity reference standards

Tivozanib impurity standards

16 characterised compounds linked to Tivozanib are catalogued here, from named pharmacopoeial impurities to synthesis intermediates and breakdown products. Highlights of the range are 2 metabolites or hydroxylated analogues.

16reference materials

2metabolites

Parent API

Tivozanib

CAS: 475108-18-0
Formula: C₂₂H₁₉ClN₄O₅
MW: 454.9 g/mol
Code: ZX-006865

Batches are supplied with a certificate of analysis, and the supporting spectra can be sent ahead of a purchase order so your QA team can review them. Laboratories use them to validate related-substance methods, set specification limits under ICH Q3A and Q3B, and identify unknown peaks in stability samples.

By impurity type

Metabolites2Hydroxy, desmethyl and conjugated forms

Counts are based on product names. One compound can fall into more than one type.

All Tivozanib reference materials

1–16 of 16 standards

1-(2-Chloro-4-((6,7-dihydroxyquinolin-4-yl)oxy)phenyl)-3-(5-methylisoxazol-3-yl)urea

Formula: C₂₀H₁₅ClN₄O₅
MW: 426.81 g/mol

ZX-011884

1-(2-Chloro-4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-3-ethylurea

Formula: C₂₀H₂₀ClN₃O₄
MW: 401.84 g/mol

ZX-011885

1-(2-Chloro-4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-3-methylurea

Formula: C₁₉H₁₈ClN₃O₄
MW: 387.82 g/mol

ZX-011886

1-(2-Chloro-4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)urea

Formula: C₁₈H₁₆ClN₃O₄
MW: 373.79 g/mol

ZX-011887

2-Chloro-4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline

CAS: 286371-44-6
Formula: C₁₇H₁₅ClN₂O₃
MW: 330.8 g/mol

ZX-012003

2'-Nitro-4',5'-dimethoxyacetophenone

CAS: 4101-32-0
Formula: C₁₀H₁₁NO₅
MW: 225.2 g/mol

ZX-031433

3-(2-Chloro-4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-1,1-dimethylurea

Formula: C₂₀H₂₀ClN₃O₄
MW: 401.84 g/mol

ZX-012047

4-(3-Chloro-4-(3-(5-methylisoxazol-3-yl)ureido)phenoxy)-6,7-dimethoxyquinoline 1-oxide

Formula: C₂₂H₁₉ClN₄O₆
MW: 470.86 g/mol

ZX-012115

4-Chloro-6-methoxyquinolin-7-ol

CAS: 205448-31-3
Formula: C₁₀H₈ClNO₂
MW: 209.63 g/mol

ZX-028399

6,7-Dimethoxyquinolin-4(1H)-one

CAS: 127285-54-5
Formula: C₁₁H₁₁NO₃
MW: 205.21 g/mol

ZX-035057

beta-Hydroxybutyronitrile

CAS: 4368-06-3
Formula: C₄H₇NO
MW: 85.1 g/mol

ZX-042599

Tivozanib

CAS: 475108-18-0
Formula: C₂₂H₁₉ClN₄O₅
MW: 454.9 g/mol

ZX-006865

Tivozanib Impurity A

CAS: 3051498-24-6
Formula: C₂₈H₂₄ClN₃O₅
MW: 518 g/mol

ZX-005435

Tivozanib Impurity C

CAS: 3051498-20-2
Formula: C₃₅H₂₈Cl₂N₄O₇
MW: 687.5 g/mol

ZX-005436

Tivozanib Impurity D

CAS: 1796383-31-7
Formula: C₉H₁₀N₄O₃
MW: 222.2 g/mol

ZX-005437

Tivozanib Monohydrochloride Monohydrate

CAS: 682745-41-1
Formula: C₂₂H₂₂Cl₂N₄O₆
MW: 509.3 g/mol

ZX-012892

Questions

Tivozanib impurities, answered

How many Tivozanib impurity standards does Zemixal list?

The catalogue currently lists 16 compounds for Tivozanib, including 2 metabolites or hydroxylated analogues. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.

What documents come with a Tivozanib impurity standard?

A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.

Can Zemixal make a Tivozanib impurity that is not listed?

Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.