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Pharmacopeial Impurities (EP / USP / BP)

Colchicine EP Impurity F

Reference StandardAvailable on request

Order Colchicine EP Impurity F (CAS 477-27-0) online at Zemixal. Lab and bulk packs, batch COA, fast global delivery. Packs from 10 mg.

Pack sizes
Colchicine EP Impurity F chemical structure
CAS number477-27-0
FormulaC21H23NO6
Molar mass385.4 g/mol
Physical formSolid
HS code38229090
InChIKeyPRGILOMAMBLWNG-HNNXBMFYSA-N
IUPAC nameN-[(7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

About Colchicine EP Impurity F

Colchicine EP Impurity F is supplied by Zemixal as a characterised reference material for Colchicine analysis. For your records (Reference Standard), the material is defined by CAS 477-27-0, formula C21H23NO6 and molar mass 385.4 g/mol. It is handled as a solid.

Typical applications

  • Pharmacopeial method verification
  • Impurity profiling
  • QC release testing
  • ANDA / DMF filings

Safe handling

Classified under GHS with signal word Danger and hazard statements H300, H318, H330 and H340. Read the SDS before first use.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and custom quantities are quoted on request. Every shipment includes a certificate of analysis with characterisation data. Send an enquiry through the quote panel and you get a formal offer with Incoterms and delivery time.

Reference standards for Colchicine

See every impurity, metabolite and related compound we list for this API.

Colchicine standards

Typical uses

  • Pharmacopeial method verification
  • Impurity profiling
  • QC release testing
  • ANDA / DMF filings

Applications

Pharmaceutical Manufacturing and QCResearch Labs and Universities

Grade guides

Ph. Eur. Grade (European Pharmacopoeia)

Specifications and identifiers

Specifications of Colchicine EP Impurity F
Product nameColchicine EP Impurity F
Catalogue numberZX-021289
CAS number477-27-0
IUPAC nameN-[(7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Molecular formulaC21H23NO6
Molar mass385.4 g/mol
Exact mass385.1525
GradeReference Standard
Physical formSolid
XLogP31.2
H-bond donors / acceptors2 / 6
Topological polar surface area94.1 Ų
HS code38229090
InChIKeyPRGILOMAMBLWNG-HNNXBMFYSA-N
SMILESCC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)O)OC)OC)OC
PubChem CID234105
SynonymsColchiceine, Colchicine - Impurity F, O10-Demethylcolchicine, O-Demethylcolchicine, N-((7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo(a)heptalen-7-yl)acetamide, colchicein, N-Acetyl trimethylcolchicinic acid, Coichiceine, (s)-n-(10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide, Benzo(a)heptalen-10(5H)-one, 7-acetamido-6,7-dihydro-9-hydroxy-1,2,3-trimethoxy-, Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, N-((7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7-trihydrobenzo[d]heptalen-7-yl) acetamide

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

GHS05 Corrosive
Corrosive
GHS06 Acute toxicity
Acute toxicity
GHS08 Health hazard
Health hazard

Signal word Danger

  • H300Fatal if swallowed
  • H318Causes serious eye damage
  • H330Fatal if inhaled
  • H340May cause genetic defects

Precautionary statements P203, P260, P264, P264 + P265, P270, P271, P280, P284, P301 + P316, P304 + P340, P305 + P354 + P338, P316, P317, P318, P320, P321, P330, P403 + P233, P405, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of Colchicine EP Impurity F
10 mgQuoted on request
25 mgQuoted on request
50 mgQuoted on request
100 mgQuoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about Colchicine EP Impurity F

Which CAS number identifies Colchicine EP Impurity F?
Colchicine EP Impurity F is registered under CAS 477-27-0. You may also see it listed as Colchiceine, Colchicine - Impurity F, O10-Demethylcolchicine. Our catalogue number for this item is ZX-021289.
What are the formula and molar mass of Colchicine EP Impurity F?
For Colchicine EP Impurity F, its formula is C21H23NO6 and its molar mass is 385.4 g/mol. The systematic (IUPAC) name is N-[(7S)-10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide. InChIKey PRGILOMAMBLWNG-HNNXBMFYSA-N lets you match it in any structure database.
How is Colchicine EP Impurity F used in pharmaceutical QC?
Colchicine EP Impurity F is a characterised reference material linked to Colchicine. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.
What grade and pack sizes are available for Colchicine EP Impurity F?
This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.
Which documents come with Colchicine EP Impurity F?
Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.
Can Zemixal ship Colchicine EP Impurity F to my country?
Yes. Because Colchicine EP Impurity F is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

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