Impurity reference standards

Larotrectinib impurity standards

7 characterised compounds linked to Larotrectinib are catalogued here, from named pharmacopoeial impurities to synthesis intermediates and breakdown products. Highlights of the range are 2 metabolites or hydroxylated analogues.

7reference materials

2metabolites

Parent API

Larotrectinib WS

CAS: 1223403-58-4
Formula: C₂₁H₂₂F₂N₆O₂
MW: 428.4 g/mol
Code: ZX-006599

Each lot ships with a certificate of analysis, and characterisation data such as 1H-NMR, mass spectrum and HPLC purity can be shared before you order. Laboratories use them to validate related-substance methods, set specification limits under ICH Q3A and Q3B, and identify unknown peaks in stability samples.

By impurity type

Metabolites2Hydroxy, desmethyl and conjugated forms

Counts are based on product names. One compound can fall into more than one type.

All Larotrectinib reference materials

1–7 of 7 standards

(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine

CAS: 1223404-88-3
Formula: C₁₆H₁₅F₂N₅
MW: 315.32 g/mol

ZX-025308

(S)-1-Benzyl-3-hydroxypyrrolidine-2,5-dione

CAS: 101469-91-4
Formula: C₁₁H₁₁NO₃
MW: 205.21 g/mol

ZX-025307

(S)-1-Benzylpyrrolidin-3-ol

CAS: 101385-90-4
Formula: C₁₁H₁₅NO
MW: 177.24 g/mol

ZX-030178

(S)-N-(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

CAS: 2226370-52-9
Formula: C₁₁H₁₂ClN₅O₂
MW: 281.7 g/mol

ZX-025309

5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine

CAS: 1363380-51-1
Formula: C₆H₃ClN₄O₂
MW: 198.57 g/mol

ZX-047898

Larotrectinib Sulphate WS

CAS: 1223405-08-0
Formula: C₂₁H₂₄F₂N₆O₆S
MW: 526.5 g/mol

ZX-006598

Larotrectinib WS

CAS: 1223403-58-4
Formula: C₂₁H₂₂F₂N₆O₂
MW: 428.4 g/mol

ZX-006599

Questions

Larotrectinib impurities, answered

How many Larotrectinib impurity standards does Zemixal list?

The catalogue currently lists 7 compounds for Larotrectinib, including 2 metabolites or hydroxylated analogues. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.

What documents come with a Larotrectinib impurity standard?

A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.

Can Zemixal make a Larotrectinib impurity that is not listed?

Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.