(2E)-3-(Dimethylamino)-1-(3-pyridinyl)-2-propen-1-one
- CAS
- 123367-26-0
- Formula
- C10H12N2O
- MW
- 176.21 g/mol
ZX-011799
Impurity reference standards
Nilotinib impurity standards
Zemixal lists 53 reference materials related to Nilotinib, covering the drug substance itself, its process impurities and the products it forms on storage. Among them are 1 pharmacopoeial impurity, 1 nitrosamine, 1 metabolite or hydroxylated analogue and 2 degradation products.
53reference materials
1pharmacopoeial
1nitrosamines
1metabolites
Each lot ships with a certificate of analysis, and characterisation data such as 1H-NMR, mass spectrum and HPLC purity can be shared before you order. They are bought for system suitability, peak identification, quantitation against limits and the impurity justification sections of regulatory submissions. The nitrosamine entries support ICH M7 risk assessments and confirmatory testing at trace levels.
By impurity type
Pharmacopoeial1EP, USP, BP or JP named impurities
Nitrosamines1N-nitroso impurities for ICH M7 work
Metabolites1Hydroxy, desmethyl and conjugated forms
Degradants2N-oxides, dimers, lactones and breakdown products
Counts are based on product names. One compound can fall into more than one type.
All Nilotinib reference materials
1–53 of 53 standards
3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)aniline
- CAS
- 943320-48-7
- Formula
- C10H8F3N3
- MW
- 227.19 g/mol
ZX-022280
3-(2-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
- CAS
- 641571-06-4
- Formula
- C11H10F3N3
- MW
- 241.21 g/mol
ZX-025834
3-(4-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
- CAS
- 2119583-27-4
- Formula
- C12H12F3N3
- MW
- 255.24 g/mol
ZX-012056
3-(4-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Hydrochloride
- Formula
- C12H12F3N3.ClH
- MW
- 291.7 g/mol
ZX-012057
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid
- CAS
- 641571-13-3
- Formula
- C12H9F3N2O2
- MW
- 270.21 g/mol
ZX-012059
3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic Acid
- CAS
- 641571-18-8
- Formula
- C12H9F3N2O2
- MW
- 270.21 g/mol
ZX-033935
3-[(Aminoiminomethyl)amino]-4-methylbenzoic Acid Ethyl Ester Mononitrate
- CAS
- 641569-96-2
- Formula
- C11H16N4O5
- MW
- 284.27 g/mol
ZX-033934
3-Amino-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
- CAS
- 915711-42-1
- Formula
- C19H17F3N4O
- MW
- 374.4 g/mol
ZX-025833
4-methyl-3-((4-(pyridin-2-yl)pyrimidin-2-yl)amino)benzoic acid
- CAS
- 2244129-60-8
- Formula
- C17H14N4O2
- MW
- 306.32 g/mol
ZX-012175
4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide
- CAS
- 851137-91-2
- Formula
- C17H15N5O
- MW
- 305.33 g/mol
ZX-030851
4-methyl-3-((4-(pyridin-4-yl)pyrimidin-2-yl)amino)benzoic acid
- CAS
- 2244129-62-0
- Formula
- C17H14N4O2
- MW
- 306.32 g/mol
ZX-012176
4-Methyl-N-(3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide
- CAS
- 641571-05-3
- Formula
- C28H22F3N7O
- MW
- 529.5 g/mol
ZX-030855
4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-2-yl)pyrimidin-2-yl)amino)benzamide
- CAS
- 2244128-96-7
- Formula
- C28H22F3N7O
- MW
- 529.52 g/mol
ZX-012177
4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-4-yl)pyrimidin-2-yl)amino)benzamide
- CAS
- 2244128-97-8
- Formula
- C28H22F3N7O
- MW
- 529.5 g/mol
ZX-012178
Questions
Nilotinib impurities, answered
How many Nilotinib impurity standards does Zemixal list?
The catalogue currently lists 53 compounds for Nilotinib, including 1 pharmacopoeial impurity, 1 nitrosamine, 1 metabolite or hydroxylated analogue and 2 degradation products. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.
What documents come with a Nilotinib impurity standard?
A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.
Can Zemixal make a Nilotinib impurity that is not listed?
Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.
Do you supply Nilotinib nitrosamine impurities?
Yes. 1 N-nitroso compound is listed for Nilotinib. They are used for confirmatory testing and method validation in line with ICH M7 and the nitrosamine guidance from the major regulators.