Impurity reference standards

Upadacitinib impurity standards

This page brings together 19 Upadacitinib related compounds that analytical teams use to identify, quantify and control impurities in the active ingredient and the finished dosage form. Most entries are process-related impurities, synthesis intermediates and isomers.

19reference materials

Parent API

Upadacitinib WS

CAS: 1310726-60-3
Formula: C₁₇H₁₉F₃N₆O
MW: 380.4 g/mol
Code: ZX-006889

Every standard comes with a certificate of analysis. Structure confirmation data, typically NMR, MS and chromatographic purity, is available on request. Laboratories use them to validate related-substance methods, set specification limits under ICH Q3A and Q3B, and identify unknown peaks in stability samples.

All Upadacitinib reference materials

1–19 of 19 standards

(3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidinecarboxylic acid phenylmethyl ester

CAS: 1428243-26-8
Formula: C₁₆H₂₀BrNO₃
MW: 354.24 g/mol

ZX-027467

(3S,4R)-3-Ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide

CAS: 2411540-30-0
Formula: C₂₄H₂₅F₃N₆O₃S
MW: 534.6 g/mol

ZX-022966

1-((Benzyloxy)carbonyl)-4-ethyl-2,5-dihydro-1H-pyrrole-3-carboxylic Acid

CAS: 1869118-25-1
Formula: C₁₅H₁₇NO₄
MW: 275.3 g/mol

ZX-036352

2-Bromo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine

CAS: 1201186-54-0
Formula: C₁₃H₁₀BrN₃O₂S
MW: 352.21 g/mol

ZX-040122

2-Bromo-5H-Pyrrolo[2,3-b]Pyrazine

CAS: 875781-43-4
Formula: C₆H₄BrN₃
MW: 198.02 g/mol

ZX-031584

3-Bromo-5H-pyrrolo[2,3-b]pyrazine

CAS: 1260665-49-3
Formula: C₆H₄BrN₃
MW: 198.02 g/mol

ZX-026118

5-Tosyl-5H-pyrrolo[2,3-b]pyrazin-2-amine

CAS: 1201187-46-3
Formula: C₁₃H₁₂N₄O₂S
MW: 288.33 g/mol

ZX-042640

8-((3R,4S)-4-Ethyl-1-((2,2,2-trifluoroethyl)carbamoyl)pyrrolidin-3-yl)-N-(2,2,2-trifluoroethyl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine-3-carboxamide

CAS: 2715120-86-6
Formula: C₂₀H₂₁F₆N₇O₂
MW: 505.4 g/mol

ZX-027468

8-((3R,4S)-4-Ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

CAS: 1428243-28-0
Formula: C₂₁H₂₃N₅O₂S
MW: 409.5 g/mol

ZX-027471

8-((3R,4S)-4-Ethylpyrrolidin-3-yl)-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

CAS: 1708997-43-6
Formula: C₁₄H₁₇N₅
MW: 255.32 g/mol

ZX-027470

Benzyl

CAS: 2868258-96-0
Formula: C₁₆H₂₀BrNO₃
MW: 354.24 g/mol

ZX-027473

N,N-Bis(2,2,2-trifluoroethyl)nitrous amide

CAS: 625-89-8
Formula: C₄H₄F₆N₂O
MW: 210.08 g/mol

ZX-047782

Rel-Benzyl (3R,4R)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate

CAS: 2304514-60-9
Formula: C₁₆H₂₀BrNO₃
MW: 354.24 g/mol

ZX-027474

tert-Butyl N-[5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]carbamate

CAS: 1201187-44-1
Formula: C₁₈H₂₀N₄O₄S
MW: 388.4 g/mol

ZX-027472

Upadacitinib Cyclized Impurity

CAS: 1708997-42-5
Formula: C₂₉H₂₉N₅O₄S
MW: 543.6 g/mol

ZX-027469

Upadacitinib Enantiomer

CAS: 1310726-59-0
Formula: C₁₇H₁₉F₃N₆O
MW: 380.4 g/mol

ZX-022967

Upadacitinib Hydrate

CAS: 2050057-56-0
Formula: C₃₄H₄₀F₆N₁₂O₃
MW: 778.8 g/mol

ZX-006888

Upadacitinib Monoacetyl Impurity

CAS: 18262-01-6
Formula: C₆H₈O₇
MW: 192.12 g/mol

ZX-005475

Upadacitinib WS

CAS: 1310726-60-3
Formula: C₁₇H₁₉F₃N₆O
MW: 380.4 g/mol

ZX-006889

Questions

Upadacitinib impurities, answered

What Upadacitinib reference materials are available?

The catalogue currently lists 19 compounds for Upadacitinib. Each product page shows the CAS number where one is assigned, the structure, formula and molecular weight.

What documents come with a Upadacitinib impurity standard?

A certificate of analysis travels with every lot. On request we share the characterisation set, usually 1H-NMR, mass spectrum, HPLC purity and IR, and for some materials TGA or water content. Ask for the data before ordering if your QA team needs to review it.

Can Zemixal make a Upadacitinib impurity that is not listed?

Often yes. Send the structure, name or CAS number with the quantity you need and our sourcing team checks custom synthesis options, usually from 10 mg up to gram scale, with a quoted lead time.