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Pharmacopeial Impurities (EP / USP / BP)

Naloxone EP Impurity A

Reference StandardIn stock

Order Naloxone EP Impurity A (CAS 33522-95-1) online at Zemixal. Lab and bulk packs, batch COA, fast global delivery. Ships from India to 120+ countries.

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Naloxone EP Impurity A chemical structure
CAS number33522-95-1
FormulaC16H17NO4
Molar mass287.31 g/mol
Physical formSolid
HS code38229090
Purity53.90%
InChIKeyHLMSIZPQBSYUNL-IPOQPSJVSA-N
IUPAC name(4R,4aS,7aR,12bS)-4a,9-dihydroxy-1,2,3,4,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

About Naloxone EP Impurity A

Analytical teams working on Naloxone use Naloxone EP Impurity A as a qualified comparison standard. For your records (Reference Standard), the material is defined by CAS 33522-95-1, formula C16H17NO4 and molar mass 287.31 g/mol. It is handled as a solid.

Use cases we see most often

  • Pharmacopeial method verification
  • Impurity profiling
  • QC release testing
  • ANDA / DMF filings

Storage and safety notes

It carries the GHS signal word Danger (H301, H302+H332, H302 and H312), so wear gloves and eye protection and work with good ventilation.

Order it in 10 mg, 25 mg, 50 mg and 100 mg packs or ask for a bulk quotation. You receive a certificate of analysis with characterisation data with each order. Request pricing online and we confirm availability, documentation and freight to your country.

Reference standards for Naloxone

See every impurity, metabolite and related compound we list for this API.

Naloxone standards

Typical uses

  • Pharmacopeial method verification
  • Impurity profiling
  • QC release testing
  • ANDA / DMF filings

Applications

Pharmaceutical Manufacturing and QCResearch Labs and Universities

Grade guides

Ph. Eur. Grade (European Pharmacopoeia)

Specifications and identifiers

Specifications of Naloxone EP Impurity A
Product nameNaloxone EP Impurity A
Catalogue numberZX-005830
CAS number33522-95-1
Other CAS numbers52446-24-9, 2162130-71-2
IUPAC name(4R,4aS,7aR,12bS)-4a,9-dihydroxy-1,2,3,4,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Molecular formulaC16H17NO4
Molar mass287.31 g/mol
Exact mass287.1158
GradeReference Standard
Purity / assay53.90%
Physical formSolid
XLogP30.4
H-bond donors / acceptors3 / 5
Topological polar surface area78.8 Ų
HS code38229090
InChIKeyHLMSIZPQBSYUNL-IPOQPSJVSA-N
SMILESC1C[C@]2([C@H]3CC4=C5[C@@]2(CCN3)[C@H](C1=O)OC5=C(C=C4)O)O
PubChem CID5497189
Synonyms4,5α-Epoxy-3,14-dihydroxymorphinan-6-one, (5α)-4,5-Epoxy-3,14-dihydroxymorphinan-6-one, (-)-Noroxymorphone, Noroxymorphone, 14-Hydroxydihydronormorphinone, 7,8-Dihydro-14-hydroxynormorphinone, Naltrexone Impurity B, Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-, (5alpha)-, Nor Oxymorphone, (5alpha)-4,5-Epoxy-3,14-dihydroxymorphinan-6-one, Nor Oxymorphone (1.0mg/ml in DMSO), desethenyl_naloxone

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

GHS06 Acute toxicity
Acute toxicity
GHS07 Irritant or harmful
Irritant or harmful
GHS08 Health hazard
Health hazard

Signal word Danger

  • H301Toxic if swallowed
  • H302+H332Harmful if swallowed or if inhaled
  • H302Harmful if swallowed
  • H312Harmful in contact with skin
  • H317May cause an allergic skin reaction
  • H332Harmful if inhaled
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements P233, P260, P261, P264, P270, P271, P272, P280, P284, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P317, P321, P330, P333 + P317, P342 + P316, P362 + P364, P403, P405, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of Naloxone EP Impurity A
10 mgQuoted on request
25 mgQuoted on request
50 mgQuoted on request
100 mgQuoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about Naloxone EP Impurity A

Which CAS number identifies Naloxone EP Impurity A?
Naloxone EP Impurity A is registered under CAS 33522-95-1. You may also see it listed as 4,5α-Epoxy-3,14-dihydroxymorphinan-6-one, (5α)-4,5-Epoxy-3,14-dihydroxymorphinan-6-one, (-)-Noroxymorphone. Our catalogue number for this item is ZX-005830.
What are the formula and molar mass of Naloxone EP Impurity A?
For Naloxone EP Impurity A, its formula is C16H17NO4 and its molar mass is 287.31 g/mol. The systematic (IUPAC) name is (4R,4aS,7aR,12bS)-4a,9-dihydroxy-1,2,3,4,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one. InChIKey HLMSIZPQBSYUNL-IPOQPSJVSA-N lets you match it in any structure database.
How is Naloxone EP Impurity A used in pharmaceutical QC?
Naloxone EP Impurity A is a characterised reference material linked to Naloxone. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.
What grade and pack sizes are available for Naloxone EP Impurity A?
This listing is Reference Standard grade with 53.90% purity. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.
Which documents come with Naloxone EP Impurity A?
Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.
Can Zemixal ship Naloxone EP Impurity A to my country?
Yes. Because Naloxone EP Impurity A is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

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