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Impurity Reference Standards

Stable Isotope Labelled Standards (Deuterated, 13C, 15N)

Deuterated, 13C and 15N labelled APIs, metabolites and impurities for use as internal standards in LC-MS bioanalysis and trace testing.
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Stable isotope labelled standards are the backbone of quantitative mass spectrometry. Because they share the chemistry of the analyte but differ in mass, they correct for losses during extraction and for ion suppression in the source. This sub-category lists deuterated, carbon-13 and nitrogen-15 labelled compounds, including Abemaciclib D5, Amodiaquine-d10, Aripiprazole-d8 (butyl-d8) and the labelled solvent Isopropanol-D8.

Two figures matter most. Isotopic purity tells you how much unlabelled compound is present, which can add to the analyte signal. Label position matters too, because deuterium on exchangeable positions can be lost in solution. A mass shift of at least three units helps avoid overlap with the natural isotope pattern of the analyte.

Standards come in milligram vials with a COA reporting chemical purity, isotopic enrichment and identity by NMR and MS. Labelled versions of listed impurities and nitrosamines can be made on request. Send your list through our quotation form.

Stable Isotope Labelled Standards (Deuterated, 13C, 15N): questions buyers ask

Is 13C labelling better than deuterium labelling?
Carbon-13 and nitrogen-15 labels do not exchange and give almost identical chromatographic retention to the analyte, which is ideal. Deuterated standards are cheaper and widely available but can elute slightly earlier and may lose label at exchangeable sites. Both work well when chosen and validated carefully.
How much unlabelled compound can a labelled standard contain?
Good labelled standards contain very little unlabelled material, often well below 1%. Any unlabelled content adds to the analyte response and affects the lowest calibration levels. Check isotopic purity on the COA and run a blank with internal standard only to measure its contribution in your method.
Can you label an API that is not yet in the catalogue?
Yes, custom labelled synthesis is possible for many APIs, metabolites and impurities. Feasibility depends on available labelled starting materials and the route. Send the structure, desired label type and position if you have a preference, and the quantity, and we will propose an approach and timeline.

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