Methotrexate diethyl ester

Name: Methotrexate diethyl ester
Brand: Zemixal
SKU: ZX-025567

Reference StandardAvailable on request

Buy Methotrexate diethyl ester (CAS 43170-88-3) from Zemixal. Request a quote with price, lead time and documents. Ships from India to 120+ countries.

Pack sizes

Methotrexate diethyl ester chemical structure

CAS number43170-88-3

FormulaC₂₄H₃₀N₈O₅

Molar mass510.5 g/mol

Physical formSolid

HS code38229090

InChIKeyMZRRIAJJDAPQRO-KRWDZBQOSA-N

IUPAC namediethyl (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate

About Methotrexate diethyl ester

Methotrexate diethyl ester belongs to the Methotrexate reference-standard family in the Zemixal catalogue. Key data (Reference Standard): CAS 43170-88-3, formula C24H30N8O5 and molar mass 510.5 g/mol. It is handled as a solid.

Common uses in the lab and plant

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Safe handling

Hazard communication follows GHS (Danger: H301, H311, H315 and H319). Our SDS lists exposure controls and first-aid measures.

Order it in 10 mg, 25 mg, 50 mg and 100 mg packs or ask for a bulk quotation. You receive a certificate of analysis with characterisation data with each order. Request pricing online and we confirm availability, documentation and freight to your country.

Reference standards for Methotrexate

See every impurity, metabolite and related compound we list for this API.

Methotrexate standards

Typical uses

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Applications

Pharmaceutical Manufacturing and QC Research Labs and Universities

Specifications and identifiers

Specifications of Methotrexate diethyl ester
Product name	Methotrexate diethyl ester
Catalogue number	ZX-025567
CAS number	43170-88-3
IUPAC name	diethyl (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate
Molecular formula	C₂₄H₃₀N₈O₅
Molar mass	510.5 g/mol
Exact mass	510.2339
Grade	Reference Standard
Physical form	Solid
XLogP3	1
H-bond donors / acceptors	3 / 12
Topological polar surface area	189 Å²
HS code	38229090
InChIKey	MZRRIAJJDAPQRO-KRWDZBQOSA-N
SMILES	CCOC(=O)CC[C@@H](C(=O)OCC)NC(=O)C1=CC=C(C=C1)N(C)CC2=CN=C3C(=N2)C(=NC(=N3)N)N
PubChem CID	94528
Synonyms	Diethyl methotrexate, Diethyl N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamate, (S)-Diethyl 2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate, diethyl n-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-l-glutamate, diethyl (4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamate

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

Acute toxicity

Health hazard

Signal word Danger

H301Toxic if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
H340May cause genetic defects
H351Suspected of causing cancer
H360May damage fertility or the unborn child

Precautionary statements P203, P261, P262, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P351 + P338, P316, P318, P319, P321, P330, P332 + P317, P337 + P317, P361 + P364, P362 + P364, P403 + P233, P405, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of Methotrexate diethyl ester
10 mg	Quoted on request
25 mg	Quoted on request
50 mg	Quoted on request
100 mg	Quoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about Methotrexate diethyl ester

Which CAS number identifies Methotrexate diethyl ester?

Methotrexate diethyl ester is registered under CAS 43170-88-3. You may also see it listed as Diethyl methotrexate, Diethyl N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamate, (S)-Diethyl 2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate. Our catalogue number for this item is ZX-025567.

What are the formula and molar mass of Methotrexate diethyl ester?

For Methotrexate diethyl ester, its formula is C24H30N8O5 and its molar mass is 510.5 g/mol. The systematic (IUPAC) name is diethyl (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate. InChIKey MZRRIAJJDAPQRO-KRWDZBQOSA-N lets you match it in any structure database.

How is Methotrexate diethyl ester used in pharmaceutical QC?

Methotrexate diethyl ester is a characterised reference material linked to Methotrexate. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.

What grade and pack sizes are available for Methotrexate diethyl ester?

This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.

Which documents come with Methotrexate diethyl ester?

Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.

Can Zemixal ship Methotrexate diethyl ester to my country?

Yes. Because Methotrexate diethyl ester is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

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