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Pharmacopeial Impurities (EP / USP / BP)

Methotrexate EP Impurity A

Reference StandardAvailable on request

Buy Methotrexate EP Impurity A (CAS 945-24-4) from Zemixal: C7H8N6O, COA and SDS with every lot, worldwide shipping. Catalogue no. ZX-022118.

Pack sizes
Methotrexate EP Impurity A chemical structure
CAS number945-24-4
FormulaC7H8N6O
Molar mass192.18 g/mol
Physical formSolid
HS code38229090
InChIKeyCYNARAWTVHQHDI-UHFFFAOYSA-N
IUPAC name(2,4-diaminopteridin-6-yl)methanol

About Methotrexate EP Impurity A

Methotrexate EP Impurity A belongs to the Methotrexate reference-standard family in the Zemixal catalogue. Identity at a glance (Reference Standard): CAS 945-24-4, formula C7H8N6O and molar mass 192.18 g/mol. It is handled as a solid.

Common uses in the lab and plant

  • Pharmacopeial method verification
  • Impurity profiling
  • QC release testing
  • ANDA / DMF filings

Handling and storage

It carries the GHS signal word Warning (H302), so wear gloves and eye protection and work with good ventilation.

Available as 10 mg, 25 mg, 50 mg and 100 mg. Larger or split packs can be arranged. Every shipment includes a certificate of analysis with characterisation data. Add it to your quote list and our team replies with price, lead time and shipping options within one business day.

Reference standards for Methotrexate

See every impurity, metabolite and related compound we list for this API.

Methotrexate standards

Typical uses

  • Pharmacopeial method verification
  • Impurity profiling
  • QC release testing
  • ANDA / DMF filings

Applications

Pharmaceutical Manufacturing and QCResearch Labs and Universities

Grade guides

Ph. Eur. Grade (European Pharmacopoeia)

Specifications and identifiers

Specifications of Methotrexate EP Impurity A
Product nameMethotrexate EP Impurity A
Catalogue numberZX-022118
CAS number945-24-4
IUPAC name(2,4-diaminopteridin-6-yl)methanol
Molecular formulaC7H8N6O
Molar mass192.18 g/mol
Exact mass192.076
GradeReference Standard
Physical formSolid
XLogP3-1.7
H-bond donors / acceptors3 / 7
Topological polar surface area124 Ų
HS code38229090
InChIKeyCYNARAWTVHQHDI-UHFFFAOYSA-N
SMILESC1=C(N=C2C(=NC(=NC2=N1)N)N)CO
PubChem CID70347
SynonymsMethotrexate - Impurity A (Freebase), 2,4-diamino-6-hydroxymethylpteridine, 6-Pteridinemethanol, 2,4-diamino-, 2,4-Diaminopteridine-6-ylmethanol, 2,4-Diamino-6-(hydroxymethyl)pteridine, 2,4-Pteridinediamine-6-methanol, 6-Hydroxymethyl-2,4-pteridinediamine, 2,4-Diamino-6-pteridinemethanol, 6-Pteridinemethanol, 2,4-diamino-, monohydrobromide, (2,4-Diamino-6-pteridinyl)methanol, 2,4-Diaminopteridine-6-methanol, CS-B0318

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

GHS07 Irritant or harmful
Irritant or harmful

Signal word Warning

  • H302Harmful if swallowed

Precautionary statements P264, P270, P301 + P317, P330, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of Methotrexate EP Impurity A
10 mgQuoted on request
25 mgQuoted on request
50 mgQuoted on request
100 mgQuoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about Methotrexate EP Impurity A

Which CAS number identifies Methotrexate EP Impurity A?
Methotrexate EP Impurity A is registered under CAS 945-24-4. You may also see it listed as Methotrexate - Impurity A (Freebase), 2,4-diamino-6-hydroxymethylpteridine, 6-Pteridinemethanol, 2,4-diamino-. Our catalogue number for this item is ZX-022118.
What are the formula and molar mass of Methotrexate EP Impurity A?
For Methotrexate EP Impurity A, its formula is C7H8N6O and its molar mass is 192.18 g/mol. The systematic (IUPAC) name is (2,4-diaminopteridin-6-yl)methanol. InChIKey CYNARAWTVHQHDI-UHFFFAOYSA-N lets you match it in any structure database.
How is Methotrexate EP Impurity A used in pharmaceutical QC?
Methotrexate EP Impurity A is a characterised reference material linked to Methotrexate. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.
What grade and pack sizes are available for Methotrexate EP Impurity A?
This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.
Which documents come with Methotrexate EP Impurity A?
Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.
Can Zemixal ship Methotrexate EP Impurity A to my country?
Yes. Because Methotrexate EP Impurity A is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

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