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Pharmacopeial Impurities (EP / USP / BP)

Methotrexate EP Impurity E

Reference StandardAvailable on request

Buy Methotrexate EP Impurity E (CAS 19741-14-1) from Zemixal: C15H15N7O2, COA and SDS with every lot, worldwide shipping.

Pack sizes
Methotrexate EP Impurity E chemical structure
CAS number19741-14-1
FormulaC15H15N7O2
Molar mass325.33 g/mol
Physical formSolid
HS code38229090
InChIKeyLWCXZSDKANNOAR-UHFFFAOYSA-N
IUPAC name4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoic acid

About Methotrexate EP Impurity E

Zemixal lists Methotrexate EP Impurity E for laboratories that identify, quantify or control Methotrexate and its related substances. Key data (Reference Standard): CAS 19741-14-1, formula C15H15N7O2 and molar mass 325.33 g/mol. It is handled as a solid.

Typical applications

  • Pharmacopeial method verification
  • Impurity profiling
  • QC release testing
  • ANDA / DMF filings

Handling and storage

It carries the GHS signal word Danger (H301, H315, H319 and H335), so wear gloves and eye protection and work with good ventilation.

Order it in 10 mg, 25 mg, 50 mg and 100 mg packs or ask for a bulk quotation. Every shipment includes a certificate of analysis with characterisation data. Add it to your quote list and our team replies with price, lead time and shipping options within one business day.

Reference standards for Methotrexate

See every impurity, metabolite and related compound we list for this API.

Methotrexate standards

Typical uses

  • Pharmacopeial method verification
  • Impurity profiling
  • QC release testing
  • ANDA / DMF filings

Applications

Pharmaceutical Manufacturing and QCResearch Labs and Universities

Grade guides

Ph. Eur. Grade (European Pharmacopoeia)

Specifications and identifiers

Specifications of Methotrexate EP Impurity E
Product nameMethotrexate EP Impurity E
Catalogue numberZX-022116
CAS number19741-14-1
IUPAC name4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoic acid
Molecular formulaC15H15N7O2
Molar mass325.33 g/mol
Exact mass325.1287
GradeReference Standard
Physical formSolid
XLogP3-1.1
H-bond donors / acceptors3 / 9
Topological polar surface area144 Ų
HS code38229090
InChIKeyLWCXZSDKANNOAR-UHFFFAOYSA-N
SMILESCN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)O
PubChem CID72441
SynonymsDeoxyaminopteroic acid, 4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoic acid, 4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoic acid, 2,4-Apa, 2,4-Diamino-N(10)-methylpteroic acid, 4-Deoxy-4-amino-N(10)-methylpteroic acid, 2,4-diamino-N10-methylpteroic acid, 4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoic acid, 4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoic acid, 4-[[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino]benzoic Acid, 4-Amino-4-deoxy-N-10-methylpteroic acid

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

GHS06 Acute toxicity
Acute toxicity
GHS07 Irritant or harmful
Irritant or harmful
GHS08 Health hazard
Health hazard

Signal word Danger

  • H301Toxic if swallowed
  • H315Causes skin irritation
  • H319Causes serious eye irritation
  • H335May cause respiratory irritation
  • H360May damage fertility or the unborn child

Precautionary statements P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of Methotrexate EP Impurity E
10 mgQuoted on request
25 mgQuoted on request
50 mgQuoted on request
100 mgQuoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about Methotrexate EP Impurity E

Which CAS number identifies Methotrexate EP Impurity E?
Methotrexate EP Impurity E is registered under CAS 19741-14-1. You may also see it listed as Deoxyaminopteroic acid, 4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoic acid, 4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoic acid. Our catalogue number for this item is ZX-022116.
What are the formula and molar mass of Methotrexate EP Impurity E?
For Methotrexate EP Impurity E, its formula is C15H15N7O2 and its molar mass is 325.33 g/mol. The systematic (IUPAC) name is 4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoic acid. InChIKey LWCXZSDKANNOAR-UHFFFAOYSA-N lets you match it in any structure database.
How is Methotrexate EP Impurity E used in pharmaceutical QC?
Methotrexate EP Impurity E is a characterised reference material linked to Methotrexate. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.
What grade and pack sizes are available for Methotrexate EP Impurity E?
This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.
Which documents come with Methotrexate EP Impurity E?
Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.
Can Zemixal ship Methotrexate EP Impurity E to my country?
Yes. Because Methotrexate EP Impurity E is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

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