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Pharmacopeial Impurities (EP / USP / BP)

Methotrexate EP Impurity F

Reference StandardAvailable on request

Methotrexate EP Impurity F (CAS 51865-79-3) supplier Zemixal. Lab and bulk packs, batch COA, fast global delivery. Quotes within one business day.

Pack sizes
Methotrexate EP Impurity F chemical structure
CAS number51865-79-3
FormulaC20H22N8O5
Molar mass454.4 g/mol
Physical formSolid
HS code38229090
InChIKeyFBOZXECLQNJBKD-CYBMUJFWSA-N
IUPAC name(2R)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid

About Methotrexate EP Impurity F

Zemixal lists Methotrexate EP Impurity F for laboratories that identify, quantify or control Methotrexate and its related substances. Identity at a glance (Reference Standard): CAS 51865-79-3, formula C20H22N8O5 and molar mass 454.4 g/mol. It is handled as a solid.

Common uses in the lab and plant

  • Pharmacopeial method verification
  • Impurity profiling
  • QC release testing
  • ANDA / DMF filings

Safe handling

Classified under GHS with signal word Danger and hazard statements H301, H315, H319 and H341. Read the SDS before first use.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and custom quantities are quoted on request. Every shipment includes a certificate of analysis with characterisation data. Add it to your quote list and our team replies with price, lead time and shipping options within one business day.

Reference standards for Methotrexate

See every impurity, metabolite and related compound we list for this API.

Methotrexate standards

Typical uses

  • Pharmacopeial method verification
  • Impurity profiling
  • QC release testing
  • ANDA / DMF filings

Applications

Pharmaceutical Manufacturing and QCResearch Labs and Universities

Grade guides

Ph. Eur. Grade (European Pharmacopoeia)

Specifications and identifiers

Specifications of Methotrexate EP Impurity F
Product nameMethotrexate EP Impurity F
Catalogue numberZX-022119
CAS number51865-79-3
IUPAC name(2R)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
Molecular formulaC20H22N8O5
Molar mass454.4 g/mol
Exact mass454.1713
GradeReference Standard
Physical formSolid
XLogP3-1.8
H-bond donors / acceptors5 / 12
Topological polar surface area211 Ų
HS code38229090
InChIKeyFBOZXECLQNJBKD-CYBMUJFWSA-N
SMILESCN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@H](CCC(=O)O)C(=O)O
PubChem CID72440
Synonyms(R)-Methotrexate, Methotrexate - Impurity F (Freebase), D-Amethopterin, D-Methotrexate, Methotrexate, (R)-, R-methotrexate, Methotrexate, d-, N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-D-glutamic acid, Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, D-, D-glutamic acid, N-(4-(((2,4-diamino-6-pteridyl)methyl)methylamino)benzoyl)-, D-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, (2R)-2-((4-((2,4-diaminopteridin-6-yl)methyl-methylamino)benzoyl)amino)pentanedioic acid

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

GHS06 Acute toxicity
Acute toxicity
GHS07 Irritant or harmful
Irritant or harmful
GHS08 Health hazard
Health hazard

Signal word Danger

  • H301Toxic if swallowed
  • H315Causes skin irritation
  • H319Causes serious eye irritation
  • H341Suspected of causing genetic defects
  • H351Suspected of causing cancer
  • H360May damage fertility or the unborn child
  • H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements P203, P260, P264, P264 + P265, P270, P280, P301 + P316, P302 + P352, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P405, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of Methotrexate EP Impurity F
10 mgQuoted on request
25 mgQuoted on request
50 mgQuoted on request
100 mgQuoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about Methotrexate EP Impurity F

Which CAS number identifies Methotrexate EP Impurity F?
Methotrexate EP Impurity F is registered under CAS 51865-79-3. You may also see it listed as (R)-Methotrexate, Methotrexate - Impurity F (Freebase), D-Amethopterin. Our catalogue number for this item is ZX-022119.
What are the formula and molar mass of Methotrexate EP Impurity F?
For Methotrexate EP Impurity F, its formula is C20H22N8O5 and its molar mass is 454.4 g/mol. The systematic (IUPAC) name is (2R)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid. InChIKey FBOZXECLQNJBKD-CYBMUJFWSA-N lets you match it in any structure database.
How is Methotrexate EP Impurity F used in pharmaceutical QC?
Methotrexate EP Impurity F is a characterised reference material linked to Methotrexate. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.
What grade and pack sizes are available for Methotrexate EP Impurity F?
This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.
Which documents come with Methotrexate EP Impurity F?
Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.
Can Zemixal ship Methotrexate EP Impurity F to my country?
Yes. Because Methotrexate EP Impurity F is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

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