1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one

Name: 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
Brand: Zemixal
SKU: ZX-019804

Reference StandardAvailable on request

Order 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one (CAS 2223677-58-3) online at Zemixal…

Pack sizes

1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one chemical structure

CAS number2223677-58-3

FormulaC₂₂H₂₀ClFN₄O₄

Molar mass458.9 g/mol

Physical formSolid

HS code38229090

InChIKeyHIMWAPFLBWDJMH-SZQRVLIRSA-N

IUPAC name1-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-5-hydroxypyrrolidin-2-one

About 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one

1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one is supplied by Zemixal as a characterised reference material for Afatinib analysis. Identity at a glance (Reference Standard): CAS 2223677-58-3, formula C22H20ClFN4O4 and molar mass 458.9 g/mol. It is handled as a solid.

Use cases we see most often

Metabolite identification
Stability-indicating methods
Impurity profiling

Available as 10 mg, 25 mg, 50 mg and 100 mg. Larger or split packs can be arranged. You receive a certificate of analysis with characterisation data with each order. Request pricing online and we confirm availability, documentation and freight to your country.

Reference standards for Afatinib

See every impurity, metabolite and related compound we list for this API.

Afatinib standards

Typical uses

Metabolite identification
Stability-indicating methods
Impurity profiling

Applications

Pharmaceutical Manufacturing and QC Research Labs and Universities

Specifications and identifiers

Specifications of 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
Product name	1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
Catalogue number	ZX-019804
CAS number	2223677-58-3
IUPAC name	1-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-5-hydroxypyrrolidin-2-one
Molecular formula	C₂₂H₂₀ClFN₄O₄
Molar mass	458.9 g/mol
Exact mass	458.1157
Grade	Reference Standard
Physical form	Solid
XLogP3	3.1
H-bond donors / acceptors	2 / 8
Topological polar surface area	96.8 Å²
HS code	38229090
InChIKey	HIMWAPFLBWDJMH-SZQRVLIRSA-N
SMILES	C1COC[C@H]1OC2=C(C=C3C(=C2)N=CN=C3NC4=CC(=C(C=C4)F)Cl)N5C(CCC5=O)O
PubChem CID	130345348
Synonyms	Des-(4-dimethylamino-2-en-1-oxo)butylamino 6-(5-Hydroxy-pyrrolidin-2-on-1-yl) Afatinib

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

No GHS classification is on file for this item. Handle it as an unknown laboratory chemical and request the SDS with your quotation.

Pack sizes

Pack sizes of 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
10 mg	Quoted on request
25 mg	Quoted on request
50 mg	Quoted on request
100 mg	Quoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one

Which CAS number identifies 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one?

1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one is registered under CAS 2223677-58-3. You may also see it listed as Des-(4-dimethylamino-2-en-1-oxo)butylamino 6-(5-Hydroxy-pyrrolidin-2-on-1-yl) Afatinib. Our catalogue number for this item is ZX-019804.

What are the formula and molar mass of 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one?

For 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one, its formula is C22H20ClFN4O4 and its molar mass is 458.9 g/mol. The systematic (IUPAC) name is 1-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-5-hydroxypyrrolidin-2-one. InChIKey HIMWAPFLBWDJMH-SZQRVLIRSA-N lets you match it in any structure database.

How is 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one used in pharmaceutical QC?

1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one is a characterised reference material linked to Afatinib. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.

What grade and pack sizes are available for 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one?

This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.

Which documents come with 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one?

Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.

Can Zemixal ship 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one to my country?

Yes. 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one ships worldwide by express courier, air cargo or sea freight, quoted on the Incoterm you prefer, with full export documents.

More Afatinib standards

More in Metabolites & Degradation Products

(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy) quinazoline-4,6-diamine

CAS: 314771-76-1
Formula: C₁₈H₁₆ClFN₄O₂
MW: 374.8 g/mol

ZX-019805

Afatinib Impurity C

CAS: 945553-91-3
Formula: C₂₄H₂₅ClFN₅O₃
MW: 485.9 g/mol

ZX-019803

Afatinib Impurity AFT-8

CAS: 2323570-72-3
Formula: C₂₄H₂₇ClFN₅O₄
MW: 504 g/mol

ZX-019806

Afatinib Hydroxy impurity

CAS: 2223677-61-8
Formula: C₂₀H₁₉ClFN₅O₂
MW: 415.8 g/mol

ZX-019807

(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine

CAS: 314771-88-5
Formula: C₁₈H₁₄ClFN₄O₄
MW: 404.8 g/mol

ZX-019808

(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide

CAS: 2223677-60-7
Formula: C₁₉H₁₆ClFN₄O₃
MW: 402.8 g/mol

ZX-019809

Afatinib dimaleate

CAS: 850140-73-7
Formula: C₃₂H₃₃ClFN₅O₁₁
MW: 718.1 g/mol

ZX-020496

(S,Z)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

CAS: 1680184-59-1
Formula: C₂₄H₂₅ClFN₅O₃
MW: 485.9 g/mol

ZX-020497

Have a list of compounds to price?

Paste up to 200 CAS numbers into Bulk CAS lookup, or send one enquiry for everything in your quote list. We reply with price, lead time and documents.

Bulk CAS lookup Open quote list