1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
- CAS
- 2223677-58-3
- Formula
- C22H20ClFN4O4
- MW
- 458.9 g/mol
ZX-019804
API Impurities
Afatinib Impurity C
Reference StandardAvailable on request
Afatinib Impurity C (CAS 945553-91-3) supplier Zemixal. Lab and bulk packs, batch COA, fast global delivery. Packs from 10 mg.
CAS number945553-91-3
FormulaC24H25ClFN5O3
Molar mass485.9 g/mol
Physical formSolid
HS code38229090
InChIKeyULXXDDBFHOBEHA-QDLOVBKTSA-N
IUPAC name(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
About Afatinib Impurity C
Analytical teams working on Afatinib use Afatinib Impurity C as a qualified comparison standard. Key data (Reference Standard): CAS 945553-91-3, formula C24H25ClFN5O3 and molar mass 485.9 g/mol. It is handled as a solid.
Where it is used
- Analytical method development
- Method validation (AMV)
- QC release testing
- ANDA / DMF filings
Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and custom quantities are quoted on request. You receive a certificate of analysis with characterisation data with each order. Request pricing online and we confirm availability, documentation and freight to your country.
Reference standards for Afatinib
See every impurity, metabolite and related compound we list for this API.
Afatinib standardsTypical uses
- Analytical method development
- Method validation (AMV)
- QC release testing
- ANDA / DMF filings
Applications
Specifications and identifiers
| Product name | Afatinib Impurity C |
|---|---|
| Catalogue number | ZX-019803 |
| CAS number | 945553-91-3 |
| IUPAC name | (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide |
| Molecular formula | C24H25ClFN5O3 |
| Molar mass | 485.9 g/mol |
| Exact mass | 485.163 |
| Grade | Reference Standard |
| Physical form | Solid |
| XLogP3 | 3.6 |
| H-bond donors / acceptors | 2 / 8 |
| Topological polar surface area | 88.6 Ų |
| HS code | 38229090 |
| InChIKey | ULXXDDBFHOBEHA-QDLOVBKTSA-N |
| SMILES | CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@@H]4CCOC4 |
| PubChem CID | 10163178 |
| Synonyms | (R)-Afatinib, Afatinib R Isomer, Afatinib (R)-Isomer, Afatinib, (R)-, R-afatinib, Afatinib Impurity 3, Afatinib Impurity 130, (R)-Afatinib(R)-BIBW 2992 |
Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.
Safety and GHS hazards
No GHS classification is on file for this item. Handle it as an unknown laboratory chemical and request the SDS with your quotation.
Pack sizes
| 10 mg | Quoted on request | |
| 25 mg | Quoted on request | |
| 50 mg | Quoted on request | |
| 100 mg | Quoted on request |
Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.
Questions about Afatinib Impurity C
Which CAS number identifies Afatinib Impurity C?
Afatinib Impurity C is registered under CAS 945553-91-3. You may also see it listed as (R)-Afatinib, Afatinib R Isomer, Afatinib (R)-Isomer. Our catalogue number for this item is ZX-019803.
What are the formula and molar mass of Afatinib Impurity C?
For Afatinib Impurity C, its formula is C24H25ClFN5O3 and its molar mass is 485.9 g/mol. The systematic (IUPAC) name is (E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide. InChIKey ULXXDDBFHOBEHA-QDLOVBKTSA-N lets you match it in any structure database.
How is Afatinib Impurity C used in pharmaceutical QC?
Afatinib Impurity C is a characterised reference material linked to Afatinib. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.
What grade and pack sizes are available for Afatinib Impurity C?
This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.
Which documents come with Afatinib Impurity C?
Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.
Can Zemixal ship Afatinib Impurity C to my country?
Yes. Afatinib Impurity C ships worldwide by express courier, air cargo or sea freight, quoted on the Incoterm you prefer, with full export documents.
More Afatinib standards
More in API Impurities
(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy) quinazoline-4,6-diamine
- CAS
- 314771-76-1
- Formula
- C18H16ClFN4O2
- MW
- 374.8 g/mol
ZX-019805
(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
- CAS
- 314771-88-5
- Formula
- C18H14ClFN4O4
- MW
- 404.8 g/mol
ZX-019808
(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide
- CAS
- 2223677-60-7
- Formula
- C19H16ClFN4O3
- MW
- 402.8 g/mol
ZX-019809
(S,Z)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
- CAS
- 1680184-59-1
- Formula
- C24H25ClFN5O3
- MW
- 485.9 g/mol
ZX-020497
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