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Solvents (HPLC & GC)

HPLC & LC-MS Grade Solvents

Gradient HPLC and LC-MS grade solvents with low UV cut-off, low residue and filtered packing for reliable chromatographic baselines.
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Chromatographers notice solvent quality first as baseline noise, ghost peaks or drifting retention. The HPLC and LC-MS grades in this sub-category are filtered and tested to keep those problems away. Alongside the usual acetonitrile and methanol you will find less common mobile-phase and normal-phase solvents, such as 1,4-Dioxan for HPLC, 1-Propyl alcohol for HPLC at 99.9%, 1,2-Dichloroethane for HPLC and 1-Octanol for HPLC.

For UV detection, the key figures are UV cut-off and absorbance at your working wavelength. For gradient work, a gradient-grade test showing no extra peaks across the run is more telling than a single absorbance value. LC-MS work adds a limit on metal ions such as sodium and potassium, which otherwise form adduct ions.

Bottles are amber glass, rinsed and capped to stop particle and plasticiser contamination, in sizes from 1 L to 4 L. Lot COAs report water, residue on evaporation and UV transmission. Please plan flammable solvent orders with sea or air routes in mind, as limits apply per package.

HPLC & LC-MS Grade Solvents: questions buyers ask

What is a gradient-grade test and why does it matter?
In a gradient-grade test the solvent is run through a blank gradient on an HPLC system and the chromatogram is checked for peaks. A solvent can pass a simple absorbance test yet still release impurities that concentrate on the column and elute during the gradient. The test confirms the solvent will not add ghost peaks to your runs.
Should I filter HPLC grade solvents before use?
Our HPLC grades are already filtered through fine membranes during packing, so routine filtration is usually unnecessary and can even add contamination from filters or glassware. Filter buffers and aqueous phases you prepare yourself. Degassing remains useful, either online in the instrument or by brief sonication under vacuum.
Why do LC-MS methods need a different grade from HPLC-UV methods?
Mass spectrometers detect compounds that UV ignores, including traces of metal salts, plasticisers and surfactants. These raise background ions, cause adducts and suppress analyte signal. LC-MS grade solvents carry tighter limits on such contaminants, which keeps sensitivity high and reduces source cleaning.

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