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Solvents (HPLC & GC)

Laboratory & Synthesis Solvents

Anhydrous, stabilised and synthesis-grade solvents such as 2-MeTHF, dioxolane and glacial acetic acid for reaction work and scale-up.
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Synthesis chemists pick solvents for solubility, boiling point, dryness and how easily they come out at work-up. This sub-category supplies reaction solvents in grades suited to the flask rather than the instrument. Examples include Acetonitrile anhydrous 99.8%, 1-Butanol anhydrous 99.8%, 2-Methyltetrahydrofuran 98%, 1,3-Dioxolane and Acetic acid glacial at 99.9985%.

Water content is usually the deciding figure for organometallic, acylation and coupling reactions. Anhydrous grades are dried and packed under inert gas. For general synthesis, a 99% grade is often enough and costs less. 2-MeTHF is worth a look as a greener alternative to THF, with better phase separation from water and a higher boiling point.

  • Anhydrous grades for moisture-sensitive chemistry
  • Stabilised ethers to limit peroxide formation
  • Larger packs for kilo-lab and pilot runs

Containers range from septum-capped bottles to steel drums. Each lot ships with a COA and SDS, and solvents can be consolidated with your reagents in a single quote panel enquiry.

Laboratory & Synthesis Solvents: questions buyers ask

Is 2-MeTHF a direct replacement for THF?
Often but not always. 2-MeTHF dissolves similar substrates, supports Grignard and lithiation chemistry and separates cleanly from water, which simplifies work-up. Its higher boiling point and slightly lower polarity can change reaction rates and selectivity. Run a small comparison before switching an established process.
How do I keep an anhydrous solvent dry after opening?
Withdraw solvent by syringe or cannula through the septum under a positive pressure of dry nitrogen or argon. Avoid pouring from an opened bottle. For long use periods, store over activated molecular sieves of the right pore size, and check water by Karl Fischer titration before critical reactions.
Why buy glacial acetic acid at such high purity?
Very high purity acetic acid is used where trace metals or organic impurities would affect results, such as in trace analysis, electronic etching or sensitive catalysis. For routine synthesis a standard grade is enough. Match the grade to the most sensitive step in your process to avoid paying for purity you do not need.

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