Methotrexate

Name: Methotrexate
Brand: Zemixal
SKU: ZX-004219

IP/BP/USPAvailable on request

Buy Methotrexate (CAS 59-05-2) from Zemixal. Lab and bulk packs, batch COA, fast global delivery. Packs from 1 kg. Part of our Oncology APIs range.

Pack sizes

CAS number59-05-2

FormulaC₂₀H₂₂N₈O₅

Molar mass454.4 g/mol

Physical formPowder

HS code2933

Purity99.6%

InChIKeyFBOZXECLQNJBKD-ZDUSSCGKSA-N

IUPAC name(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid

About Methotrexate

Methotrexate is part of the Zemixal oncology APIs range. Key data (IP/BP/USP): CAS 59-05-2, formula C20H22N8O5 and molar mass 454.4 g/mol. Expect yellow crystalline powder (Results: conforms).

Use cases we see most often

Polymer & resin production
Pharmaceutical formulation

Handling and storage

Hazard communication follows GHS (Danger: H301, H315, H319 and H340). Our SDS lists exposure controls and first-aid measures.

Available as 1 kg, 5 kg and 25 kg. Larger or split packs can be arranged. Every shipment includes a batch certificate of analysis and a 16-section SDS. Add it to your quote list and our team replies with price, lead time and shipping options within one business day.

Reference standards for Methotrexate

See every impurity, metabolite and related compound we list for this API.

Methotrexate standards

Typical uses

Polymer & resin production
Pharmaceutical formulation

Applications

Pharmaceutical Manufacturing and QC

Grade guides

IP Grade (Indian Pharmacopoeia)BP Grade (British Pharmacopoeia)USP Grade (United States Pharmacopeia)

Specifications and identifiers

Specifications of Methotrexate
Product name	Methotrexate
Catalogue number	ZX-004219
CAS number	59-05-2
IUPAC name	(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
Molecular formula	C₂₀H₂₂N₈O₅
Molar mass	454.4 g/mol
Exact mass	454.1713
Grade	IP/BP/USP
Purity / assay	99.6%
Physical form	Powder
Appearance	Yellow crystalline powder (Results: conforms)
XLogP3	-1.8
H-bond donors / acceptors	5 / 12
Topological polar surface area	211 Å²
HS code	2933
InChIKey	FBOZXECLQNJBKD-ZDUSSCGKSA-N
SMILES	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
PubChem CID	126941
Synonyms	Amethopterin, Ledertrexate, Emtexate, L-Amethopterin, Amethopterine, Medsatrexate, Methoblastin, Methotextrate, Brimexate, Emthexate, Texate, EMT 25,299

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

Acute toxicity

Irritant or harmful

Health hazard

Signal word Danger

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H340May cause genetic defects
H360May damage fertility or the unborn child

Precautionary statements P203, P264, P264 + P265, P270, P280, P301 + P316, P302 + P352, P305 + P351 + P338, P318, P321, P330, P332 + P317, P337 + P317, P362 + P364, P405, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of Methotrexate
1 kg	Quoted on request
5 kg	Quoted on request
25 kg	Quoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about Methotrexate

Which CAS number identifies Methotrexate?

Methotrexate is registered under CAS 59-05-2. You may also see it listed as Amethopterin, Ledertrexate, Emtexate. Our catalogue number for this item is ZX-004219.

What are the formula and molar mass of Methotrexate?

For Methotrexate, its formula is C20H22N8O5 and its molar mass is 454.4 g/mol. The systematic (IUPAC) name is (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid. InChIKey FBOZXECLQNJBKD-ZDUSSCGKSA-N lets you match it in any structure database.

How is Methotrexate used in pharmaceutical QC?

Methotrexate is a characterised reference material linked to Methotrexate. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.

What grade and pack sizes are available for Methotrexate?

This listing is IP/BP/USP grade with 99.6% purity. Standard packs are 1 kg, 5 kg, 25 kg. Larger quantities and custom packing can be quoted on request.

Which documents come with Methotrexate?

Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.

Can Zemixal ship Methotrexate to my country?

Yes. Because Methotrexate is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

Other grades with CAS 59-05-2

Methotrexate

CAS: 59-05-2
Formula: C₂₀H₂₂N₈O₅
MW: 454.4 g/mol

ZX-006646

Methotrexate, 98%

CAS: 59-05-2
Formula: C₂₀H₂₂N₈O₅
MW: 454.4 g/mol

ZX-011038

More Methotrexate standards

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