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APIs

Oncology APIs

Kinase inhibitors, cytotoxics, proteasome inhibitors and hormone antagonists for oncology formulation, research and analytical development.
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Oncology APIs demand special care at every step, from synthesis to dispensing, because many are highly potent or cytotoxic. This sub-category lists a focused group of molecules covering several mechanisms. They include the kinase inhibitors Imatinib and Erlotinib, the proteasome inhibitor Bortezomib, the aromatase inhibitor Anastrozole, the immunomodulator Lenalidomide, and the cytotoxics Cyclophosphamide, Gemcitabine HCl and Irinotecan.

Buyers often need small quantities for development batches, so batch size and containment arrangements are part of the first conversation. Form also matters: imatinib is used as the mesylate, often in a defined crystal form, and injectable products need grades suited to sterile manufacture. Confirm the form, pharmacopoeia and impurity limits on your enquiry.

Oncology APIs are packed in sealed, labelled containers inside secondary packaging that limits exposure if damaged. Each lot ships with the manufacturer's COA and an SDS detailing handling precautions. We confirm any export or import permits before shipment.

Oncology APIs: questions buyers ask

What precautions apply when receiving cytotoxic APIs?
Inspect outer packaging for damage before opening, and open inner containers only in a containment area such as a cytotoxic safety cabinet or isolator. Staff should wear suitable gloves, gowns and respiratory protection as set out in the SDS. Have a spill kit ready and dispose of waste as cytotoxic material.
Why is the crystal form of imatinib mesylate specified?
Imatinib mesylate exists in more than one crystal form, and products in different markets use specific forms. The form affects stability, solubility and patent status. Specify the form that matches your dossier, and expect identification data such as XRPD on the COA.
Can I buy milligram quantities of an oncology API for research?
Small research quantities are often possible, either from the API manufacturer or as a reference standard. For analytical method work, a working standard with characterisation data may suit better. Tell us the purpose and quantity, and we will suggest whether the API or a reference standard is the better fit.

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