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API Process Intermediates & Related Compounds

Methotrexate Dimethylamide

Reference StandardIn stock

Methotrexate Dimethylamide (CAS 71074-44-7) supplier Zemixal: C22H27N9O4, COA and SDS with every lot, worldwide shipping.

Pack sizes
Methotrexate Dimethylamide chemical structure
CAS number71074-44-7
FormulaC22H27N9O4
Molar mass481.5 g/mol
Physical formSolid
HS code2933
InChIKeyBHFZGVOUGIGQGR-HNNXBMFYSA-N
IUPAC name(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-(dimethylamino)-5-oxopentanoic acid

About Methotrexate Dimethylamide

Methotrexate Dimethylamide is part of the Zemixal API Process Intermediates & Related Compounds range. Key data (Reference Standard): CAS 71074-44-7, formula C22H27N9O4 and molar mass 481.5 g/mol. It is handled as a solid.

Common uses in the lab and plant

  • API route development
  • Impurity fate & purge studies
  • Analytical method development

Handling and storage

Hazard communication follows GHS (Warning: H302, H312, H315 and H319). Our SDS lists exposure controls and first-aid measures.

Order it in 10 mg, 25 mg, 50 mg and 100 mg packs or ask for a bulk quotation. You receive a batch certificate of analysis and a 16-section SDS with each order. Send an enquiry through the quote panel and you get a formal offer with Incoterms and delivery time.

Reference standards for Methotrexate

See every impurity, metabolite and related compound we list for this API.

Methotrexate standards

Typical uses

  • API route development
  • Impurity fate & purge studies
  • Analytical method development

Applications

Pharmaceutical Manufacturing and QCResearch Labs and Universities

Specifications and identifiers

Specifications of Methotrexate Dimethylamide
Product nameMethotrexate Dimethylamide
Catalogue numberZX-012604
CAS number71074-44-7
IUPAC name(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-(dimethylamino)-5-oxopentanoic acid
Molecular formulaC22H27N9O4
Molar mass481.5 g/mol
Exact mass481.2186
GradeReference Standard
Physical formSolid
XLogP3-1.9
H-bond donors / acceptors4 / 11
Topological polar surface area194 Ų
HS code2933
InChIKeyBHFZGVOUGIGQGR-HNNXBMFYSA-N
SMILESCN(C)C(=O)CC[C@@H](C(=O)O)NC(=O)C1=CC=C(C=C1)N(C)CC2=CN=C3C(=N2)C(=NC(=N3)N)N
PubChem CID100284
SynonymsMethotrexate N,N-dimethylamide, N2-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-N,N-dimethyl-L-glutamine, Methotrexate-gamma-dimethylamide, Mxt-gamma-dma, Methotrexate Dimethylamide (>90%), Methotrexate Dimethylamide (>85%), L-Glutamine, N2-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-N,N-dimethyl-, N2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-N5,N5-dimethyl-L-glutamine

Lot values are stated on the batch certificate of analysis. Ask for a typical COA with your quotation.

Safety and GHS hazards

GHS07 Irritant or harmful
Irritant or harmful

Signal word Warning

  • H302Harmful if swallowed
  • H312Harmful in contact with skin
  • H315Causes skin irritation
  • H319Causes serious eye irritation
  • H332Harmful if inhaled
  • H335May cause respiratory irritation

Precautionary statements P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification summarised from public GHS notifications. It can vary with grade and concentration, so always follow the SDS supplied with your lot.

Pack sizes

Pack sizes of Methotrexate Dimethylamide
10 mgQuoted on request
25 mgQuoted on request
50 mgQuoted on request
100 mgQuoted on request

Need a different size? Bulk drums and custom packing are quoted on request through the quote form on this page.

Questions about Methotrexate Dimethylamide

Which CAS number identifies Methotrexate Dimethylamide?
Methotrexate Dimethylamide is registered under CAS 71074-44-7. You may also see it listed as Methotrexate N,N-dimethylamide, N2-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-N,N-dimethyl-L-glutamine, Methotrexate-gamma-dimethylamide. Our catalogue number for this item is ZX-012604.
What are the formula and molar mass of Methotrexate Dimethylamide?
For Methotrexate Dimethylamide, its formula is C22H27N9O4 and its molar mass is 481.5 g/mol. The systematic (IUPAC) name is (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-(dimethylamino)-5-oxopentanoic acid. InChIKey BHFZGVOUGIGQGR-HNNXBMFYSA-N lets you match it in any structure database.
How is Methotrexate Dimethylamide used in pharmaceutical QC?
Methotrexate Dimethylamide is a characterised reference material linked to Methotrexate. Laboratories use it to identify and quantify this impurity during method development and validation, stability work, batch release testing and regulatory submissions.
What grade and pack sizes are available for Methotrexate Dimethylamide?
This listing is Reference Standard grade. Standard packs are 10 mg, 25 mg, 50 mg, 100 mg. Larger quantities and custom packing can be quoted on request.
Which documents come with Methotrexate Dimethylamide?
Each lot ships with a batch certificate of analysis and a 16-section GHS safety data sheet. A typical COA or specification sheet can be shared with the quotation before you order.
Can Zemixal ship Methotrexate Dimethylamide to my country?
Yes. Because Methotrexate Dimethylamide is classed as hazardous, it travels in UN-approved packaging as dangerous goods under IATA or IMDG rules, with the export paperwork your broker needs.

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