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APIs

Antidiabetic, Hormone & Metabolic APIs

Antidiabetic, steroid, hormone, bone and metabolic APIs, from bisphosphonates to corticosteroids and fertility agents, for generic manufacturers.
47 productsCOA + SDS with every lot
47 products · page 1 of 2
GridList
Dexamethasone
CAS
50-02-2
Formula
C22H29FO5
MW
392.5 g/mol
ZX-038100
Finasteride
CAS
98319-26-7
Formula
C23H36N2O2
MW
372.5 g/mol
ZX-038327

This sub-category brings together APIs that act on the endocrine system and metabolism. It covers corticosteroids such as Betamethasone and Deflazacort, fertility and hormone agents including Clomiphene Citrate, Allylestrenol and Danazol, the dopamine agonist Cabergoline, the bisphosphonate Alendronate Sodium and the gout drug Allopurinol, along with oral antidiabetic molecules.

Hormonal and steroid APIs are often highly potent, so manufacturers need containment measures and occupational exposure limits as part of their planning. Many steroids are used in micronised form for creams, inhalers or low-dose tablets, which makes particle size a key specification. Cabergoline and similar low-dose drugs require tight content uniformity in the final product.

  • Corticosteroids for topical, oral and injectable products
  • Hormones and fertility agents in low-dose formulations
  • Bone and metabolic drugs in high-volume tablets

APIs ship in sealed containers with the manufacturer's COA and an SDS that covers potent compound handling. State the pharmacopoeia and particle size you need when sending your enquiry.

Antidiabetic, Hormone & Metabolic APIs: questions buyers ask

Why are steroid APIs often supplied micronised?
Topical, inhaled and low-dose oral products need very fine, uniform particles so the drug spreads evenly and dissolves quickly. Micronisation reduces particle size to a few microns. The specification usually gives a particle size distribution such as d90 below a set value, measured by laser diffraction on each lot.
How should potent hormone APIs be handled on receipt?
Open and dispense them in contained areas such as isolators or ventilated enclosures, with suitable protective equipment. Follow the exposure guidance in the SDS and your own occupational limits. Clean equipment with validated methods to avoid cross-contamination of other products made in the same facility.
Can you supply alendronate sodium as the trihydrate?
Alendronate sodium is normally supplied as the trihydrate, which is the form described in the main pharmacopoeias. The water content is part of the specification and is checked on each lot. Confirm that your formulation and dossier use the trihydrate, since dose calculations depend on the form.

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