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Chemical grade

GC Grade chemicals

Solvents for gas chromatography with high GC purity, low non-volatile residue and few peaks that interfere with FID, ECD or MS.

What the grade guarantees

In gas chromatography the solvent is injected with the sample, so every volatile impurity can appear as a peak. GC grade solvents are purified for a clean chromatogram in the retention window you care about and for low non-volatile residue, which otherwise accumulates in the liner.

Variants to know

  • Capillary GC grade is checked for interfering peaks with an FID.
  • Pesticide residue grade is concentrated before testing and checked with an ECD, because residue methods evaporate large volumes.
  • Headspace grade covers DMSO, DMF and DMAc tested for low volatile organics, for residual solvent analysis to ICH Q3C.
  • GC-MS grade is tested for low background in mass spectrometry.

Typical specification points

GC purity of 99.8 percent or more, non-volatile residue of 1 to 3 mg/L, water of 0.02 to 0.05 percent and, for residue grades, ECD-active impurities expressed as a lindane equivalent.

When to choose it and documentation

Pick the variant that matches your detector and sample preparation. Each lot comes with a COA and a GHS SDS. See Solvents (HPLC and GC) for products.

GC Grade products

1–24 of 150 products
Questions

About GC Grade

Can I use HPLC grade hexane for GC?
Sometimes, but HPLC grade is tested for UV absorbance rather than GC peaks. Trace volatile impurities that are invisible to a UV detector can show up on an FID or ECD, so a GC or residue grade is the safer choice for trace work.
Why is DMSO used for headspace residual solvent testing?
DMSO has a high boiling point, dissolves most drug substances and elutes well after common residual solvents. A headspace grade is tested to show that it contributes no measurable peaks for the solvents listed in ICH Q3C.
What does a lindane equivalent mean on a COA?
Pesticide residue grade solvents report ECD-active impurities as if they were lindane, after concentrating the solvent. It gives a single figure for electron-capturing contaminants that would interfere with organochlorine residue methods.

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