(1E)-N-Methyl-2-[1-(phenylmethyl)-1H-indol-5-yl]ethenesulfonamide
- CAS
- 894351-84-9
- Formula
- C18H18N2O2S
- MW
- 326.4 g/mol
ZX-044008
Heterocyclic Building Blocks
Indole Derivatives
Indoles, carbazolones, azaindoles and pyrrolopyrimidines for tryptamine, alkaloid, kinase inhibitor and materials chemistry, from gram packs to kilos.
(1R,3R)-1-(Benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide
- CAS
- 1370438-57-5
- Formula
- C19H17N3O3
- MW
- 335.4 g/mol
ZX-045062
(2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol
- CAS
- 1374639-77-6
- Formula
- C12H14ClN3O
- MW
- 251.71 g/mol
ZX-011062
1-[Tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridine
- CAS
- 1093759-49-9
- Formula
- C16H26N2Si
- MW
- 274.48 g/mol
ZX-040490
1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole
- CAS
- 683229-61-0
- Formula
- C15H20BNO2
- MW
- 257.14 g/mol
ZX-042733
1-Triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-5-ol
- CAS
- 685514-01-6
- Formula
- C16H26N2OSi
- MW
- 290.48 g/mol
ZX-035166
The indole ring appears in tryptophan, serotonin and a long list of natural products and drugs, which keeps indole building blocks in steady demand. This sub-category supplies simple and substituted indoles, fused and aza analogues. Examples include 2-Methyl indole, 1-Methyl indole, 2-Phenylindole, 3,3-Diindolylmethane, 1,2,3,4-Tetrahydrocarbazol-4-one (an ondansetron intermediate) and (2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol, used in ribociclib synthesis.
Indoles are electron-rich and react readily at C-3, so they can oxidise or polymerise when exposed to air, light or acid. Purity is often reflected in colour, with pure indoles being white to pale yellow. N-protected and N-alkyl indoles are more stable and give different reactivity, which matters when planning a route.
Products ship in amber bottles, sealed and sometimes under nitrogen. Each lot comes with a COA and SDS. Gram packs are typical, and pharmaceutical intermediates such as the carbazolone and pyrrolopyrimidine can be quoted at kilogram scale for process development.
Indole Derivatives: questions buyers ask
Why does indole substitution happen mainly at C-3?
Attack at C-3 by an electrophile gives an intermediate in which the positive charge is stabilised by the nitrogen lone pair without disrupting the benzene ring. This makes C-3 the most nucleophilic position. When C-3 is blocked, substitution moves to C-2 or onto nitrogen, depending on conditions.
What is 3,3'-diindolylmethane studied for?
3,3'-Diindolylmethane forms from indole-3-carbinol in cruciferous vegetables. It is studied for effects on oestrogen metabolism and cell signalling, and is sold as a dietary supplement ingredient in some markets. Research grades are used in cell and animal studies, and purity by HPLC is reported on the COA.
How should indole building blocks be stored?
Store them in tightly closed amber containers, cool and dry, away from acids and oxidisers. Indoles slowly darken on exposure to air and light. If a sample has turned pink or brown, a quick recrystallisation or filtration through silica usually restores purity for synthetic use.
Nearby categories
Pyridine Derivatives 491Pyrimidines, Pyrazines & Pyridazines 286Quinolines & Isoquinolines 145Imidazoles & Benzimidazoles 242Triazoles, Tetrazoles & Triazines 124Thiophenes, Thiazoles & Thiadiazoles 273Furans, Pyrans & Coumarins 157Piperidines, Piperazines & Morpholines 447Pyrroles, Pyrrolidines & Pyrazoles 325Other Heterocyclic Building Blocks 182
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