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Heterocyclic Building Blocks

Other Heterocyclic Building Blocks

Azepines, benzoxazoles, macrocyclic amines, oxcarbazepine-type scaffolds and other heterocycles outside the main ring families.
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Some ring systems do not belong to the major heterocycle families, yet they are vital for particular drugs, ligands and materials. This sub-category collects them. Examples include 1,4,8,11-Tetraazacyclotetradecane (cyclam), a macrocyclic chelator, 10-Methoxy-5H-dibenz[b,f]azepine-5-carboxamide related to oxcarbazepine, (3S)-3-Aminoazepane-1-carboxylic acid tert-butyl ester, 2-Mercaptobenzoxazole, 2-Benzoxazolinone and the Hsp90 inhibitor 17-AAG.

Because the range is diverse, the critical specifications vary. Macrocycles such as cyclam must be free of metal contamination for chelation and radiolabelling work. Chiral azepanes need confirmed configuration. Benzoxazoles are used as intermediates, rubber chemicals and photoinitiator components. Natural product analogues like 17-AAG are research compounds that need cold, dark storage.

Products ship in sealed containers suited to each compound, cold-packed where needed. Each lot comes with a COA and SDS. Search by name, CAS or formula, or send a structure through the quote panel if you need a related ring that is not yet listed.

Other Heterocyclic Building Blocks: questions buyers ask

What is cyclam used for?
Cyclam is a 14-membered macrocycle with four nitrogens that binds transition metals very strongly. It is used in coordination chemistry, catalysis and as a scaffold for radiopharmaceutical chelators. A bicyclam derivative, plerixafor, is used clinically to mobilise stem cells. Metal-free material is important for these uses.
Why are dibenzazepine compounds listed here?
Dibenz[b,f]azepine is the ring system of carbamazepine and oxcarbazepine, two widely used antiepileptic drugs. The methoxy carboxamide derivative is an intermediate and known impurity in oxcarbazepine manufacture. Analysts and process chemists use it to develop and control the synthetic route.
How should 17-AAG be stored and handled?
17-AAG is a geldanamycin analogue and potent Hsp90 inhibitor. Store it at minus 20 °C, protected from light and moisture. Dissolve it in DMSO for stock solutions and keep aliquots frozen. Handle it as a cytotoxic compound, with gloves and suitable containment, following the SDS.

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