(14BRS)-1,2,3,4,10,14b-Hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine Maleate
- CAS
- 135928-31-3
- Formula
- C20H21N3O4
- MW
- 367.4 g/mol
ZX-033864
Heterocyclic Building Blocks
Pyridine Derivatives
Substituted pyridines, pyridinones, aminomethyl pyridines and pyridyl piperazines for kinase inhibitors, agrochemicals and ligand design.
(4-Methoxy-3,5-dimethylpyridin-2-yl)methanol Hydrochloride
- CAS
- 96300-88-8
- Formula
- C9H14ClNO2
- MW
- 203.66 g/mol
ZX-034833
(5-(Ethylsulfonyl)pyridin-2-yl) methanamine hydrochloride, 97%
- CAS
- 1637311-15-9
- Formula
- C8H13ClN2O2S
- MW
- 236.72 g/mol
ZX-010700
(6-(Aminomethyl)pyridin-2-yl)methanol dihydrochloride, 97%
- CAS
- 1803592-67-7
- Formula
- C7H12Cl2N2O
- MW
- 211.09 g/mol
ZX-010702
(6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone
- CAS
- 613678-03-8
- Formula
- C12H17N3O
- MW
- 219.28 g/mol
ZX-033691
(6R,7R)-7-Amino-8-oxo-3-((4-(pyridin-4-yl)thiazol-2-yl)thio)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- CAS
- 1809412-65-4
- Formula
- C15H12N4O3S3
- MW
- 392.5 g/mol
ZX-044863
(E)-N,N-Dimethyl-4-((2-((5-((Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenylbut-1-en-1-yl)pyridin-2-yl)oxy)ethyl)amino)but-2-enamide
- CAS
- 2052130-80-8
- Formula
- C30H29F4N5O2
- MW
- 567.6 g/mol
ZX-041421
(Z)-1-((2-((4-(2-((Furan-2-ylmethyl)sulfinyl)acetamido)but-2-en-1-yl)oxy)pyridin-4-yl)methyl)piperidine 1-oxide
- CAS
- 169899-18-7
- Formula
- C22H29N3O5S
- MW
- 447.5 g/mol
ZX-044679
1-(4-Chloro-3-methoxyphenyl)-2-(pyridin-4-yl)ethanone
- CAS
- 342435-01-2
- Formula
- C14H12ClNO2
- MW
- 261.7 g/mol
ZX-010704
Pyridine is one of the most common rings in approved drugs, valued for its basic nitrogen, hydrogen bond acceptance and metabolic stability. This sub-category supplies pyridines with a wide range of substitution patterns and functional handles. Examples include (5-Bromo-3-methoxypyridin-2-yl)methanol, (6-(Aminomethyl)pyridin-2-yl)methanol dihydrochloride, 1-(4-Pyridyl)piperazine, 1-(3-Hydroxypyridin-4-yl)ethanone and the pyridinone 1-(4-Methoxyphenyl)-5-methyl-2(1H)-pyridinone.
Substitution pattern is everything with pyridines. The 2-, 3- and 4-positions differ sharply in reactivity, so halogens at C-2 or C-4 undergo substitution easily, while those at C-3 need cross-coupling. Buyers should check the exact positions against the drawing, as names can be confusing. Many aminopyridines are supplied as hydrochloride salts for stability, so adjust weights for the counter-ion when planning reactions.
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Pyridine Derivatives: questions buyers ask
Why are 2-halopyridines more reactive than 3-halopyridines?
The ring nitrogen withdraws electron density from the 2- and 4-positions and stabilises the negative intermediate formed during nucleophilic substitution. Halogens at those positions are displaced by amines and alkoxides under mild conditions. A halogen at C-3 lacks this activation and normally needs palladium or copper catalysis.
How do I free-base an aminomethylpyridine dihydrochloride?
Dissolve the salt in water, add a base such as sodium hydroxide or carbonate until strongly basic, and extract the free amine into an organic solvent such as dichloromethane. Dry and concentrate carefully. Alternatively, add a tertiary amine base directly to the reaction to release the amine in situ.
Are pyridinones the same as hydroxypyridines?
2- and 4-hydroxypyridines exist mainly in their pyridinone tautomer form, with a carbonyl and an N-H or N-substituent. N-substituted pyridinones, such as the methoxyphenyl example, are locked in that form. This affects reactivity, hydrogen bonding and solubility, and pyridinones appear in drugs such as pirfenidone.
Nearby categories
Pyrimidines, Pyrazines & Pyridazines 286Indole Derivatives 160Quinolines & Isoquinolines 145Imidazoles & Benzimidazoles 242Triazoles, Tetrazoles & Triazines 124Thiophenes, Thiazoles & Thiadiazoles 273Furans, Pyrans & Coumarins 157Piperidines, Piperazines & Morpholines 447Pyrroles, Pyrrolidines & Pyrazoles 325Other Heterocyclic Building Blocks 182
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