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Biochemicals

Bioactive Small Molecules

Receptor ligands, natural flavonoids, alkaloids, phospholipids and pharmacological tool compounds for screening, signalling and mechanism studies.
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GridList
17-DMAG
CAS
467214-20-6
Formula
C32H48N4O8
MW
616.7 g/mol
ZX-002736

Bioactive small molecules are the probes researchers use to switch pathways on and off. This sub-category covers receptor agonists and antagonists, enzyme inhibitors, natural flavonoids and alkaloids, and membrane lipids used to build model systems. Typical entries include (-)-Huperzine A 98%+, a cholinesterase inhibitor, (+)-Catechin hydrate, (±)-Chlorpheniramine maleate ≥99% and 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC).

Researchers judge these compounds on identity, purity by HPLC and stereochemistry, since an enantiomer can have very different activity. Solubility in DMSO or water and stability in solution are also practical concerns when building screening plates. Where a compound is also an approved drug, check whether your purpose calls for a research grade or the API grade from our APIs division.

Compounds are supplied in milligram to gram packs, sealed and labelled with storage conditions. Temperature-sensitive items travel with cold packs. Every lot ships with a COA showing purity and identity data.

Bioactive Small Molecules: questions buyers ask

How should I prepare stock solutions for screening?
Dissolve the compound in DMSO or another compatible solvent at a known concentration, typically 10 mM, and store aliquots frozen in tightly sealed tubes. Avoid repeated freeze-thaw cycles and water uptake by DMSO, which can cause precipitation. Check solubility limits before making concentrated stocks of poorly soluble compounds.
Why does stereochemistry matter so much for these compounds?
Biological targets are chiral, so the two enantiomers of a molecule can differ greatly in potency, selectivity or toxicity. A racemic sample contains both and may give misleading results. Check that the listing names the correct stereoisomer, and use the COA data to confirm optical purity where it is reported.
Are these compounds suitable for in-vivo studies?
They are sold for research use. For animal work, consider purity, endotoxin levels and the vehicle, and follow your institution's ethics approvals. If you need a material made under pharmaceutical controls, ask whether an API grade is available, since that may be a better fit for formulation work.

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