(3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid, 98%
- CAS
- 486460-00-8
- Formula
- C15H18F3NO4
- MW
- 333.3 g/mol
ZX-002164
Biochemicals
Protected Amino Acids (Fmoc, Boc, Cbz)
Fmoc, Boc and Cbz protected amino acids and chiral protected amines for solid-phase peptide synthesis and medicinal chemistry.
Boc-D-arginine hydrochloride, monohydrate, 99%
- CAS
- 114622-81-0
- Formula
- C11H25ClN4O5
- MW
- 328.79 g/mol
ZX-002169
Peptide chemists need amino acids that react only where intended, which is why the alpha-amine and reactive side chains are protected. This sub-category supplies Fmoc, Boc and Cbz derivatives along with side-chain protected forms and protected chiral amines. Items include Boc-D-alanine 99%, Boc-D-arginine hydrochloride monohydrate, Boc-4-nitro-L-phenylalanine and (3R)-N-Boc-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid, a known sitagliptin intermediate.
Choosing a protecting group comes down to your synthesis strategy. Fmoc chemistry uses base for deprotection and acid for final cleavage, while Boc chemistry relies on acid throughout. Cbz is removed by hydrogenolysis and is common in solution-phase work. Check enantiomeric purity, free amino acid content and the side-chain protection on each derivative before ordering.
Most protected amino acids are stable solids that keep well refrigerated and dry. They are packed in sealed bottles from 5 g to 1 kg. Each lot ships with a COA showing HPLC purity and optical rotation.
Protected Amino Acids (Fmoc, Boc, Cbz): questions buyers ask
How do I choose between Fmoc and Boc strategies?
Fmoc chemistry is the default for most solid-phase work because it avoids repeated strong acid and uses milder cleavage. Boc chemistry still suits difficult sequences prone to aggregation, and some thioester and long peptides. Your resin, linker and the side-chain protecting groups available should all fit the same strategy.
What impurities matter most in protected amino acids?
The main ones are the opposite enantiomer, free unprotected amino acid, dipeptides formed during protection, and acetate or other residues that cap growing chains. Even low levels can lead to deletion or truncated sequences in long peptides. Check the COA for HPLC purity and enantiomeric data before use in critical syntheses.
Can protected amino acids be shipped without cooling?
Most Fmoc, Boc and Cbz derivatives are stable for the length of a normal transit at ambient temperature. Long-term storage should be refrigerated and dry. A few sensitive derivatives travel with cold packs, and this is noted on the product page and the quotation.
Nearby categories
Amino Acids & Derivatives 172Peptide Synthesis Reagents 102Carbohydrates & Sugars 312Enzymes, Proteins & Inhibitors 215Bioactive Small Molecules 362Lipids & Fatty Acids 55Biological Buffers 172Cell Culture Reagents 294Molecular Biology, Nucleotides & Purification Reagents 338Microbiology Culture Media & Agars 59Diagnostic & Clinical Reagents 175Biological Detergents & Surfactants 65Antibiotics & Antimycotics for Research 81Natural Products, Vitamins & Phytochemicals 222
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