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Organic Building Blocks

Aldehydes & Ketones

Aliphatic, aromatic and cyclic aldehydes and ketones, diones and protected carbonyls for condensations, reductive amination and heterocycle synthesis.
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(-)-Acorenone
CAS
5956-05-8
Formula
C15H24O
MW
220.35 g/mol
ZX-041630
(+)-Fenchone
CAS
4695-62-9
Formula
C10H16O
MW
152.23 g/mol
ZX-040810
(E)-Citral
CAS
141-27-5
Formula
C10H16O
MW
152.23 g/mol
ZX-041802
[8]-Gingerol
CAS
23513-08-8
Formula
C19H30O4
MW
322.4 g/mol
ZX-033546

The carbonyl group is one of the most versatile handles in organic synthesis, taking part in condensations, additions, reductions and ring formations. This sub-category supplies aldehydes and ketones of many kinds. Examples include 1,3-Cyclohexanedione, 1,3-Indandione, 1,4-Cyclohexanedione monoethylene acetal and the diaryl ketone (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone, a dapagliflozin intermediate.

Aldehydes oxidise in air to carboxylic acids, so their purity can change during storage, and some are supplied with stabilisers. Cyclic 1,3-diones are acidic and exist partly as enols, which affects their reactivity in Michael and Knoevenagel reactions. Mono-protected diones, such as the ethylene acetal, let you react one carbonyl while the other is masked. Check the COA for free dione content before selective work.

Products ship in sealed bottles, many under inert gas, from gram packs to kilograms. Each lot comes with a COA and SDS. Search by name, CAS or formula to find positional isomers quickly.

Aldehydes & Ketones: questions buyers ask

How can I limit oxidation of aldehydes in storage?
Store aldehydes cold, in full containers under nitrogen or argon, away from light. Air oxidation forms the corresponding carboxylic acid, which can poison some reactions. For sensitive work, check purity by NMR or GC before use, and wash out acid with a mild base or distil if needed.
Why use a mono-protected cyclohexanedione?
1,4-Cyclohexanedione monoethylene acetal has one ketone masked as an acetal, so only the free ketone reacts. This allows selective additions, olefinations or reductive aminations at one position. The acetal is removed afterwards under mild acid to reveal the second ketone for further steps.
Are diaryl ketones like the dapagliflozin intermediate available in bulk?
Many pharmaceutical ketone intermediates are produced at scale in India. We can quote kilogram and larger quantities, with a COA showing purity and key impurities. For process work, ask for a recent lot COA and sample to confirm suitability before placing a commercial order.

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