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Organic Building Blocks

Nitriles & Cyanides

Aliphatic and aromatic nitriles, malononitriles and cyano building blocks for heterocycle synthesis, liquid crystals and API intermediates.
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The nitrile group is small, polar and remarkably versatile. It can become an amine, an acid, an amide, a ketone or a heterocycle such as a tetrazole. This sub-category supplies aryl, benzyl and alkyl nitriles and related cyano compounds. Examples include (Ethoxymethylene)malononitrile for pyrazole and pyrimidine synthesis, (2-Chlorophenyl)acetonitrile, 2,3-Dichlorobenzonitrile, 1-Naphthylacetonitrile and (S)-4-Cyano-4'-(2-methylbutyl)biphenyl, a chiral liquid crystal component.

Most organic nitriles are stable and easy to store, but some are toxic because they can release cyanide in the body. Inorganic cyanide salts are a separate, more hazardous class handled with strict controls. Buyers should check the SDS, and for halogenated benzonitriles, confirm regioisomer identity because positional isomers are common impurities.

Products ship in sealed bottles or drums with a COA and SDS. Gram packs are available for research, and many items can be supplied at kilogram scale for process development. Search by CAS to separate close isomers.

Nitriles & Cyanides: questions buyers ask

How are nitriles converted into tetrazoles?
Nitriles react with sodium azide in the presence of a Lewis acid or ammonium salt to form 5-substituted 1H-tetrazoles. Tetrazoles are used as carboxylic acid bioisosteres in drugs such as the sartan antihypertensives. Azide reactions need care because hydrazoic acid is toxic and explosive.
What is ethoxymethylene malononitrile used for?
It is a reactive building block that condenses with hydrazines, amidines and amines to form pyrazoles, pyrimidines and other heterocycles bearing amino and cyano groups. These products are intermediates for kinase inhibitors, dyes and agrochemicals. It should be stored dry, as it hydrolyses slowly.
Are aryl nitriles hazardous to handle?
Aryl nitriles are generally less acutely toxic than aliphatic nitriles, which can release cyanide through metabolism. Both should be handled with gloves in a fume cupboard and kept away from strong acids. Read the SDS for each compound, as toxicity varies widely across this class.

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