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Organic Building Blocks

Amines & Anilines

Primary, secondary and tertiary amines, anilines, diamines, guanidines and quaternary salts for coupling, catalysis and pharmaceutical synthesis.
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Amines are central to drug chemistry, since most APIs contain at least one basic nitrogen. This sub-category covers aliphatic and aromatic amines, chiral diamines, guanidine bases and quaternary ammonium salts. Examples include (1R,2R)-(−)-1,2-Diaminocyclohexane, a ligand scaffold for Jacobsen and Trost catalysts, 1,1,3,3-Tetramethylguanidine, a strong organic base, (3-Chlorophenyl)(phenyl)methanamine and its hydrochloride, and (±)-Synephrine.

Free amines absorb carbon dioxide and water from air and many darken through oxidation, so the free base and the salt form behave differently in storage. Hydrochloride salts are often more stable and easier to weigh but need a base to release the amine in reactions. For chiral amines, enantiomeric excess decides their value in asymmetric synthesis and resolution.

  • Chiral diamines for ligands and organocatalysts
  • Strong guanidine bases for eliminations and alkylations
  • Aryl and benzhydryl amines as API intermediates

Each lot ships with a COA and SDS. Liquids are packed under nitrogen to limit discolouration.

Amines & Anilines: questions buyers ask

Why do aniline samples turn brown over time?
Anilines oxidise slowly in air and light, forming coloured quinone-type products even at low levels. The colour often appears before purity drops much. Store anilines in amber containers under nitrogen, cool and dark. For sensitive reactions, distil or filter through a short silica plug to remove the coloured impurities.
When should I buy an amine as its hydrochloride salt?
Choose the salt when the free amine is volatile, air sensitive or hard to handle, or when you need accurate weighing. Salts store well and resist oxidation. Release the free amine with a base in situ or by extraction. Remember to adjust the weight for the HCl when calculating equivalents.
What makes tetramethylguanidine useful as a base?
Tetramethylguanidine is a strong, non-nucleophilic organic base that dissolves in most organic solvents. It promotes alkylations, eliminations and condensations without metal salts and is easy to remove by acidic wash. It is also used in peptide chemistry and as a catalyst for some polymerisations.

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