Boronic Acids & Esters

The Suzuki-Miyaura reaction made boronic acids one of the most purchased building block classes in medicinal chemistry. This sub-category lists aryl, heteroaryl and alkyl boronic acids, their pinacol esters and specialist chiral boron reagents. Examples include (3,5-Dichlorophenyl)boronic acid, (2-Iodo-5-methoxyphenyl)boronic acid, 1-Ethyl-1H-pyrazole-4-boronic acid pinacol ester, 1-Butylboronic acid and (+)-B-Chlorodiisopinocampheylborane (DIP-Chloride) for asymmetric ketone reduction.

Boronic acids can dehydrate to boroxines on storage, which shifts the apparent assay but rarely harms coupling. Pinacol esters are more stable and easier to purify, though slightly less reactive. Heteroaryl boronic acids, especially 2-pyridyl types, are prone to protodeboronation, so their esters or trifluoroborates are often preferred. Ortho-substituted partners such as the iodo-methoxyphenyl acid allow sequential couplings at two sites.

Products ship in sealed bottles, refrigerated where needed. Each lot comes with a COA and SDS. Gram quantities are typical, with kilogram supply possible for common coupling partners.