((1S,2R)-1-(3-Fluorophenyl)cyclopropane-1,2-diyl)dimethanol
- CAS
- 1369767-20-3
- Formula
- C11H13FO2
- MW
- 196.22 g/mol
ZX-046245
Organic Building Blocks
Fluorinated Building Blocks
Trifluoromethyl, trifluoromethoxy and fluoroaryl building blocks plus fluorinated alcohols and ethers for drug discovery and materials.
(1R,2S)-2-(2,3-Difluorophenyl)cyclopropanamine Hydrochloride
- CAS
- 1643378-59-9
- Formula
- C9H10ClF2N
- MW
- 205.63 g/mol
ZX-032652
(1R,2S)-2-(3-Chloro-4-fluorophenyl)cyclopropan-1-amine
- CAS
- 2227766-79-0
- Formula
- C9H9ClFN
- MW
- 185.62 g/mol
ZX-036290
(2-Fluoro-4-(trifluoromethoxy)phenyl)methanamine
- CAS
- 1240257-11-7
- Formula
- C8H7F4NO
- MW
- 209.14 g/mol
ZX-041284
(2S)-2-(Phenylmethoxycarbonylamino)-6-[(2,2,2-trifluoroacetyl)amino]hexanoic acid
- CAS
- 14905-30-7
- Formula
- C16H19F3N2O5
- MW
- 376.33 g/mol
ZX-042250
(5-Bromo-2-chlorophenyl)(4-fluorophenyl)methanone
- CAS
- 915095-85-1
- Formula
- C13H7BrClFO
- MW
- 313.55 g/mol
ZX-009554
(E)-3-(3-(Trifluoromethyl)phenyl)acrylaldehyde, 98%
- CAS
- 262268-58-6
- Formula
- C10H7F3O
- MW
- 200.16 g/mol
ZX-009555
(E)-4-(((4-Fluorophenyl)imino)methyl)phenol, 98%
- CAS
- 942485-62-3
- Formula
- C13H10FNO
- MW
- 215.22 g/mol
ZX-009556
(R)-2-(3-(Trifluoromethyl)phenyl)propanoic Acid
- CAS
- 150360-28-4
- Formula
- C10H9F3O2
- MW
- 218.17 g/mol
ZX-042786
(R)-3,3,3-Trifluoro-2-methoxy-2-phenylpropanoic Acid
- CAS
- 20445-31-2
- Formula
- C10H9F3O3
- MW
- 234.17 g/mol
ZX-045293
Fluorine changes how a molecule behaves. It can block metabolism, raise lipophilicity, tune pKa and strengthen binding, which is why a large share of new drugs and agrochemicals contain it. This sub-category supplies fluorinated building blocks, including (Trifluoromethoxy)benzene, (4-(Trifluoromethyl)phenyl)methanol, 1,1,1-Trifluoro-2-propanol, (5-Bromo-2-chlorophenyl)(4-fluorophenyl)methanone and the fluorinated ether 1,1,2,2-Tetrafluoroethyl 2,2,2-trifluoroethyl ether, used in battery electrolytes.
Installing fluorine late in a synthesis can be difficult, so many chemists prefer to start from a building block that already carries the CF3, OCF3 or fluoroaryl group. Check positional isomers and the absence of defluorinated by-products on the COA. Fluorinated solvents and ethers are chosen for low flammability and electrochemical stability. Fluorinated alcohols such as trifluoropropanol also act as strong hydrogen-bond donors in reactions.
Products are packed in sealed glass or fluoropolymer-lined containers, from gram packs to kilograms. Each lot ships with a COA and SDS. Search by formula to scan isomers across the range.
Fluorinated Building Blocks: questions buyers ask
Why add a trifluoromethyl group to a drug molecule?
A CF3 group is strongly electron-withdrawing and lipophilic. It can block metabolic oxidation at that site, raise membrane permeability and improve binding through hydrophobic contacts. It also changes the pKa of nearby groups. Medicinal chemists often swap a methyl or chlorine for CF3 to tune these properties.
What are fluorinated ethers used for in batteries?
Hydrofluoroethers such as tetrafluoroethyl trifluoroethyl ether are used as co-solvents or diluents in lithium battery electrolytes. They are non-flammable, chemically stable at high voltage and weakly coordinating, which helps form localised high-concentration electrolytes with better safety and longer cycle life.
Is OCF3 similar to CF3 in its effects?
Both are lipophilic and electron-withdrawing, but OCF3 is more lipophilic and adopts a different shape, sitting out of the ring plane. It is valued in drugs and agrochemicals for metabolic stability. Trifluoromethoxy arenes are harder to make late in a route, so buying the building block saves several steps.
Nearby categories
Aldehydes & Ketones 601Carboxylic Acids & Salts 1,083Esters & Lactones 789Amides, Ureas & Carbamates 291Acid Halides & Anhydrides 211Amines & Anilines 760Nitriles & Cyanides 279Nitro, Azo & Hydrazine Compounds 445Alcohols & Polyols 440Phenols & Naphthols 189Ethers, Acetals & Epoxides 277Halogenated Hydrocarbons 385Sulfur Compounds (Thiols, Sulfides, Sulfonates) 698Boronic Acids & Esters 103Organosilicon Compounds & Silanes 162Hydrocarbons (Alkanes, Alkenes & Arenes) 323Chiral Building Blocks 66Other Organic Building Blocks 847
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